ID   YOSC_SCHPO              Reviewed;         124 AA.
AC   Q9P7L1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Thioredoxin domain-containing protein C21C3.12c;
GN   ORFNames=SPBC21C3.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB76048.1; -; Genomic_DNA.
DR   PIR; T50356; T50356.
DR   RefSeq; NP_596592.1; NM_001022512.2.
DR   AlphaFoldDB; Q9P7L1; -.
DR   SMR; Q9P7L1; -.
DR   STRING; 4896.SPBC21C3.12c.1; -.
DR   iPTMnet; Q9P7L1; -.
DR   MaxQB; Q9P7L1; -.
DR   PaxDb; Q9P7L1; -.
DR   PRIDE; Q9P7L1; -.
DR   EnsemblFungi; SPBC21C3.12c.1; SPBC21C3.12c.1:pep; SPBC21C3.12c.
DR   GeneID; 2540715; -.
DR   KEGG; spo:SPBC21C3.12c; -.
DR   PomBase; SPBC21C3.12c; -.
DR   VEuPathDB; FungiDB:SPBC21C3.12c; -.
DR   eggNOG; KOG3425; Eukaryota.
DR   HOGENOM; CLU_120161_2_0_1; -.
DR   InParanoid; Q9P7L1; -.
DR   OMA; HVYVGNM; -.
DR   PhylomeDB; Q9P7L1; -.
DR   PRO; PR:Q9P7L1; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004601; F:peroxidase activity; ISS:PomBase.
DR   GO; GO:0047134; F:protein-disulfide reductase (NAD(P)) activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IC:PomBase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR045108; TXNDC17-like.
DR   InterPro; IPR010357; TXNDC17_dom.
DR   PANTHER; PTHR12452; PTHR12452; 1.
DR   Pfam; PF06110; DUF953; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..124
FT                   /note="Thioredoxin domain-containing protein C21C3.12c"
FT                   /id="PRO_0000372630"
FT   DOMAIN          37..124
FT                   /note="Thioredoxin"
FT   ACT_SITE        39
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  13932 MW;  AA6910D3F12CADFF CRC64;
     MLLPLKESLE STLANVAKNE TLFVAYLASV DPRTKQPWCP TVRAALPLFN NAFNSSKKLN
     VVHVYVGNMP QWKTPHNEFR VKFGISAVPT LGKYTRDAQG NLKTSLLVDY DCLDANKFSK
     FIDI