YOSF_SCHPO
ID YOSF_SCHPO Reviewed; 522 AA.
AC Q9P7K9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Putative aldehyde dehydrogenase-like protein C21C3;
DE EC=1.2.1.-;
GN ORFNames=SPBC21C3.15c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAB76051.1; -; Genomic_DNA.
DR PIR; T50359; T50359.
DR RefSeq; NP_596595.1; NM_001022515.2.
DR AlphaFoldDB; Q9P7K9; -.
DR SMR; Q9P7K9; -.
DR BioGRID; 277036; 1.
DR STRING; 4896.SPBC21C3.15c.1; -.
DR iPTMnet; Q9P7K9; -.
DR MaxQB; Q9P7K9; -.
DR PaxDb; Q9P7K9; -.
DR PRIDE; Q9P7K9; -.
DR EnsemblFungi; SPBC21C3.15c.1; SPBC21C3.15c.1:pep; SPBC21C3.15c.
DR GeneID; 2540508; -.
DR KEGG; spo:SPBC21C3.15c; -.
DR PomBase; SPBC21C3.15c; -.
DR VEuPathDB; FungiDB:SPBC21C3.15c; -.
DR eggNOG; KOG2454; Eukaryota.
DR HOGENOM; CLU_005391_1_0_1; -.
DR InParanoid; Q9P7K9; -.
DR OMA; PVAHHVC; -.
DR PhylomeDB; Q9P7K9; -.
DR PRO; PR:Q9P7K9; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Oxidoreductase; Reference proteome.
FT CHAIN 1..522
FT /note="Putative aldehyde dehydrogenase-like protein C21C3"
FT /id="PRO_0000310350"
FT ACT_SITE 239
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007,
FT ECO:0000255|PROSITE-ProRule:PRU10008"
FT ACT_SITE 273
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007,
FT ECO:0000255|PROSITE-ProRule:PRU10008"
FT SITE 138
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 522 AA; 57571 MW; A1AB04CCB7A18B20 CRC64;
MSSTLTCYCP GDGSLLGEVK LFNKSDIDQS IILAEEAQKE WKSTSFAERR NFLKALKENI
IRNQDKYAEI ACKDTGKTLV DAAFGEILVT LEKINWTLAN GEQSLRPTKR PNSLLTSYKG
GYVKYEPLGV IAALVSWNYP LHNALGPIIS ALFAGNAIVV KGSELTAWST HQYCEMVRSL
LQSMGHSPEL VQCITCLPDV ADHLTSHSGI KHITFIGSQP IAKLVAASAA KQLTPLCLEL
GGKDPCILTD DHRLEEILSI VMRGVFQSAG QNCIGIERII ALDGVYDTII TKLYNRISTM
RLGMYTQNDV DMGAMVSNNR FDHLESLIQD AVSKGARLVY GGHRFQHPKY PKGNYFLPTL
LVDATNEMKI AQEECFAPIA LVFRAKSPEH ALEIANGTEF GLGASVFGRD KQLCQYFTDN
LETGMVAVND FGAFYLLQMP FGGCKKSGYG RFAGYEGLRG ICNSKAIAYD RFSAIHTGIP
PAVDYPIPDS QKAWQFVRGL MGTVYGAWIS LVPNVYQLWR NS
