ID   YOXD_BACSU              Reviewed;         238 AA.
AC   P14802;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Uncharacterized oxidoreductase YoxD;
DE            EC=1.-.-.-;
GN   Name=yoxD; OrderedLocusNames=BSU18500;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=1849493; DOI=10.1016/0378-1119(91)90111-n;
RA   Ahn K.S., Wake R.G.;
RT   "Variations and coding features of the sequence spanning the replication
RT   terminus of Bacillus subtilis 168 and W23 chromosomes.";
RL   Gene 98:107-112(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 62-238.
RC   STRAIN=168;
RX   PubMed=3118336; DOI=10.1093/nar/15.20.8501;
RA   Carrigan C.M., Haarsma J.A., Smith M.T., Wake R.G.;
RT   "Sequence features of the replication terminus of the Bacillus subtilis
RT   chromosome.";
RL   Nucleic Acids Res. 15:8501-8509(1987).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; X06168; CAA29533.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13743.1; -; Genomic_DNA.
DR   PIR; D69930; D69930.
DR   RefSeq; NP_389732.1; NC_000964.3.
DR   RefSeq; WP_004399223.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P14802; -.
DR   SMR; P14802; -.
DR   STRING; 224308.BSU18500; -.
DR   jPOST; P14802; -.
DR   PaxDb; P14802; -.
DR   PRIDE; P14802; -.
DR   EnsemblBacteria; CAB13743; CAB13743; BSU_18500.
DR   GeneID; 940090; -.
DR   KEGG; bsu:BSU18500; -.
DR   PATRIC; fig|224308.179.peg.2017; -.
DR   eggNOG; COG0300; Bacteria.
DR   InParanoid; P14802; -.
DR   OMA; HEHQPRV; -.
DR   PhylomeDB; P14802; -.
DR   BioCyc; BSUB:BSU18500-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..238
FT                   /note="Uncharacterized oxidoreductase YoxD"
FT                   /id="PRO_0000054847"
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         10..34
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   238 AA;  25299 MW;  9CC7A8D1204DF248 CRC64;
     MQSLQHKTAL ITGGGRGIGR ATALALAKEG VNIGLIGRTS ANVEKVAEEV KALGVKAAFA
     AADVKDADQV NQAVAQVKEQ LGDIDILINN AGISKFGGFL DLSADEWENI IQVNLMGVYH
     VTRAVLPEMI ERKAGDIINI SSTAGQRGAA VTSAYSASKF AVLGLTESLM QEVRKHNIRV
     SALTPSTVAS DMSIELNLTD GNPEKVMQPE DLAEYMVAQL KLDPRIFIKT AGLWSTNP