YOY6_CAEEL
ID YOY6_CAEEL Reviewed; 575 AA.
AC P34664; Q7Z143;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Uncharacterized protein ZK652.6;
GN ORFNames=ZK652.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34664-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34664-2; Sequence=VSP_017900;
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DR EMBL; FO080278; CCD62551.1; -; Genomic_DNA.
DR EMBL; FO080278; CCD62552.1; -; Genomic_DNA.
DR RefSeq; NP_001023028.2; NM_001027857.3.
DR AlphaFoldDB; P34664; -.
DR SMR; P34664; -.
DR BioGRID; 41303; 3.
DR IntAct; P34664; 2.
DR STRING; 6239.ZK652.6a; -.
DR iPTMnet; P34664; -.
DR EPD; P34664; -.
DR PaxDb; P34664; -.
DR PeptideAtlas; P34664; -.
DR EnsemblMetazoa; ZK652.6a.1; ZK652.6a.1; WBGene00022785.
DR GeneID; 176095; -.
DR KEGG; cel:CELE_ZK652.6; -.
DR UCSC; ZK652.6a.1; c. elegans. [P34664-1]
DR CTD; 176095; -.
DR WormBase; ZK652.6a; CE50501; WBGene00022785; -.
DR eggNOG; KOG1280; Eukaryota.
DR GeneTree; ENSGT00510000047171; -.
DR HOGENOM; CLU_458016_0_0_1; -.
DR InParanoid; P34664; -.
DR OrthoDB; 1008658at2759; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR PRO; PR:P34664; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022785; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; P34664; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR Gene3D; 3.30.60.90; -; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR039858; KCMF1.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF13; PTHR12268:SF13; 1.
DR Pfam; PF05605; zf-Di19; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..575
FT /note="Uncharacterized protein ZK652.6"
FT /id="PRO_0000065535"
FT ZN_FING 9..73
FT /note="ZZ-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT REGION 277..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..566
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 17
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 29
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 32
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 41
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 63
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT VAR_SEQ 1..346
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_017900"
SQ SEQUENCE 575 AA; 64182 MW; 6DCCE6E523D79035 CRC64;
MVTPLTGTHE GVSCDGCAFT AFAGNRYKCL RCSDYDLCFS CFTTKNYGDQ QTIADIPIHD
ESHPMQLILS SVDFDLVYQG DPTRHYDERK IVSFTCPYCN ITGLTERQFG THVLSQHPEA
PGYSVICPLC IGNTEMEHIQ SKETENLSVH WTEIHLHTME NLFRSTEPIT TRPVQRRPML
ARRGNRAGVS RTAAQGRPLQ DEIGAEMAAL LRNMGPDSVE DIRRFTEMMT VPLLPGIRSS
QRLMTSTGDR PTVVVESAVT HQDPNVQQVI RPLATIPIYP PTSDESGDET PQPAADSADE
SEDDNDIQEL DDMQPIVEDE ALKKDEFWKT LKTRISEEDV DLILETMKST AKVKEDIDDK
MPVWTQRPLK RLANAAQVTT TSDSEGDPGW LPLSFETTPI RSTGCGGYWS DKRFLRPRKM
QREQSVASSN AEIMEKAEIA LALIRASCLH EPVFTDPTKP DIALKEALQH LRLGEKPAKM
MEYQAAEELV NMPERDPITT GEMEVEIPDF TARGYGQIVD GNIPLGVVPE ADEAITNSED
EEIVGGETSG DDEDEQEDDE NDSQDSSVPE EINID
