YP022_YEAST
ID YP022_YEAST Reviewed; 1133 AA.
AC Q12139; D6W432;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein YPR022C;
GN OrderedLocusNames=YPR022C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP DOMAIN.
RX PubMed=9171100; DOI=10.1093/nar/25.12.2464;
RA Boehm S., Frishman D., Mewes H.-W.;
RT "Variations of the C2H2 zinc finger motif in the yeast genome and
RT classification of yeast zinc finger proteins.";
RL Nucleic Acids Res. 25:2464-2469(1997).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z49274; CAA89276.1; -; Genomic_DNA.
DR EMBL; Z71255; CAA95018.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11448.1; -; Genomic_DNA.
DR PIR; S54496; S54496.
DR RefSeq; NP_015347.1; NM_001184119.1.
DR AlphaFoldDB; Q12139; -.
DR BioGRID; 36199; 140.
DR IntAct; Q12139; 5.
DR STRING; 4932.YPR022C; -.
DR iPTMnet; Q12139; -.
DR MaxQB; Q12139; -.
DR PaxDb; Q12139; -.
DR PRIDE; Q12139; -.
DR EnsemblFungi; YPR022C_mRNA; YPR022C; YPR022C.
DR GeneID; 856133; -.
DR KEGG; sce:YPR022C; -.
DR SGD; S000006226; YPR022C.
DR VEuPathDB; FungiDB:YPR022C; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_006466_2_1_1; -.
DR InParanoid; Q12139; -.
DR OMA; EWWNHWI; -.
DR BioCyc; YEAST:G3O-34182-MON; -.
DR PRO; PR:Q12139; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q12139; protein.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF04082; Fungal_trans; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1133
FT /note="Zinc finger protein YPR022C"
FT /id="PRO_0000255976"
FT ZN_FING 31..55
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 61..91
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 130117 MW; 77F6F3C9E3760DAA CRC64;
MHGKELAGRL RKRENDNDLS PNSSSSPAER FRCPHPECNK TFSRQEHLSR HKLNHWPKEI
YVCSYVLPTT NAPCNKTFVR KDLLIRHEKR HSKVKNRLSR PSKDQISSSN KDFSKNAPYN
PSEVPLSTQS GTSTINLIKN SVNPPPSITQ ESKFRPFLQQ AQQPQQVQQS QQPQQIQQLQ
QLQFPQQLRA PLQQPMLQQQ MHPQQASPTF PSYDPRIRNN GQNGNQFFNL IFDNRTGVNG
FEVDAANNNG NGNDQNMNIN PAVQQQRYQD RNFASSSYQQ PLQPLTQDQQ QEQYFQQQKL
AQQQQQQQQQ QQQQQQLPPQ NPFGDPLTSS SSGANLSVMQ DLFSTNFLNS DPLQSFMQEL
SEAPQVSIED TFSDKNTIPP NEKPVQQDEG FQNPPVMFEL PQDNIKIPKA QPKFNDNPST
SVKDNLSSQK LNINELKRRS SKDSGVGNNS SLNYKEQLRH SMKSVPSFFH PDPLTKYKIS
KEKCQEMFSF VPELRYVSIE SIHKSLKSFW LNFHPQYGLL HKPSFHVDKQ PAILNLALIM
TGASFLGSEY REQISDPICG PLRWIIFSHA DFQPPSKTYI IQSLLLVEGY EKTSTNRYLH
ERSFLHHGTT IQLLRRTPSL GGHPLMVKTG KTSGENSIQD PQEVYKRWID FEMLKRIAFY
AFYMDTTHAV VFGYWNLFIN SNQIQLTLPC PDQVWESYDL SYETLMEHGY GSTKRDENNT
FLSALMQLMK NVIQILRNNN IRRNKVNNGG IESTPTDLES TTDWNIQSLF GKKILLAGII
SILFQCQEEV NGDYFITNFR GGITDHLGLS WKDILSFAMN YWLHEVQKSC TDPKACRIST
PSEETLTNRK IDEDNGDGLC DDDLDLLSSD NPSNCKIPVI HISQIVLRIL HHDYYIYAGA
PWRMNVPIGR DEYDMISRRI LQFAKDPYNG GVAVVYAFQF LFEMFIIKEN NVPTVVKSYN
INSDPVITRP YAIALTSLLI WSCNFALHGC EVSIWDNTEA SKDECFQPDD SNGGNILGNT
DNNGSTIANN NLKEKNNYIP IESFEVYLLR MYRNLYVDSS LDVVSFQNDV WAKASLLQHI
SNTHFLCGMM QFMRDIFNKS YWDLGREFGK LFDNCLERSL GKTSPTCHNM FDV
