YP109_YEAST
ID YP109_YEAST Reviewed; 657 AA.
AC Q02981; D6W3Q8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=ABC1 family protein YPL109C, mitochondrial;
DE Flags: Precursor;
GN OrderedLocusNames=YPL109C; ORFNames=LPH17C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP SEQUENCE REVISION.
RA Hong E.L., Cherry J.M.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP REVISION OF GENE MODEL.
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [5]
RP IDENTIFICATION OF FRAMESHIFTS.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [9]
RP IDENTIFICATION OF FRAMESHIFTS.
RX PubMed=12775844; DOI=10.1126/science.1084337;
RA Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J.,
RA Waterston R., Cohen B.A., Johnston M.;
RT "Finding functional features in Saccharomyces genomes by phylogenetic
RT footprinting.";
RL Science 301:71-76(2003).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 2470 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
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DR EMBL; U43503; AAB68252.2; -; Genomic_DNA.
DR EMBL; BK006949; DAA11324.1; -; Genomic_DNA.
DR PIR; S62012; S62012.
DR RefSeq; NP_015216.3; NM_001183923.1.
DR AlphaFoldDB; Q02981; -.
DR BioGRID; 36072; 190.
DR IntAct; Q02981; 12.
DR MINT; Q02981; -.
DR STRING; 4932.YPL109C; -.
DR MaxQB; Q02981; -.
DR PaxDb; Q02981; -.
DR PRIDE; Q02981; -.
DR DNASU; 855995; -.
DR EnsemblFungi; YPL109C_mRNA; YPL109C; YPL109C.
DR GeneID; 855995; -.
DR KEGG; sce:YPL109C; -.
DR SGD; S000006030; YPL109C.
DR VEuPathDB; FungiDB:YPL109C; -.
DR eggNOG; KOG1236; Eukaryota.
DR GeneTree; ENSGT00390000001536; -.
DR HOGENOM; CLU_006533_6_0_1; -.
DR InParanoid; Q02981; -.
DR OMA; RRDLKIM; -.
DR BioCyc; YEAST:G3O-34011-MON; -.
DR PRO; PR:Q02981; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q02981; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR CDD; cd13971; ADCK2-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR044095; ADCK2_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..15
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 16..657
FT /note="ABC1 family protein YPL109C, mitochondrial"
FT /id="PRO_0000200738"
SQ SEQUENCE 657 AA; 76176 MW; 6814CE70DBE2B97C CRC64;
MSFLKFAYRN SWRYYSKSTR HFHKIPIRQF IIPTSIAFYL TQNSFPKQNC LIYNDSLKPD
PKGDTFEMGL YVSSENELQE KLKSFRSAKI TESRNKLIRY LRIFWFGFND NIVEPVCTIL
RFLEISAIFL PLLLLYPISW FGHKLKITDT NITETRGSLI WCQLLRKALE LAGPSFIKLG
QWAGSRTDIF SHALCHELGK LHSNVTAHSL SFTLEKLSQA LKVDKIEDAF DEFNRTPIGV
GSIAQVYVGE LSQKYIDKYD NIQIGKDGNR WCAIKILHPN VRSQIRRDLK IMKFCADAIN
WIPTMEWLSL PSEVDQFSIL MNIQLDLRIE ALNLERFNEN FKNSIQVKFP KPFLPLSNRD
VMFEEHVYGL SMEKFLSTKK QINDVELCKK VSDPFVDAFL QMLILDDFVH ADLHPGNVII
RFVKTNKYGT NIISSELESY RITHDLRKKI EEDQDQDFVG KLKSVLTNYT PQICFIDTGI
ITELNEKNRI NFIALFNALA RFDGYRAGEL MIERSRTPET AIDKEVFAFK VEKLVDKVKQ
RTFTLGTVSI GDLLDQMLSM VRSHHVRMES DFVSVVVAIL LLEGIGRQLD PNLDLFESSL
PILREFGFKR EAKSLLKDAS TLSMLKIWVG LEVRQLMHLS MKQIYDLVRT DQLCPNY
