ID   YP196_YEAST             Reviewed;         470 AA.
AC   Q06595; D6W4J5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Maltose fermentation regulatory protein YPR196W;
GN   OrderedLocusNames=YPR196W; ORFNames=P9677.4;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: May regulate the transcription of maltase and maltose
CC       permease genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the MAL13 family. {ECO:0000305}.
CC   -!- CAUTION: The gene is not associated with corresponding maltase and
CC       maltose permease genes on chromosome 16 as it is the case for the other
CC       functional maltose fermentation loci, so its transcription regulation
CC       activity is speculative. {ECO:0000305}.
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DR   EMBL; U25841; AAB64625.1; -; Genomic_DNA.
DR   EMBL; AY558071; AAS56397.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11611.1; -; Genomic_DNA.
DR   PIR; S58826; S58826.
DR   RefSeq; NP_015522.1; NM_001184293.1.
DR   AlphaFoldDB; Q06595; -.
DR   BioGRID; 36367; 14.
DR   IntAct; Q06595; 1.
DR   STRING; 4932.YPR196W; -.
DR   MaxQB; Q06595; -.
DR   PaxDb; Q06595; -.
DR   PRIDE; Q06595; -.
DR   EnsemblFungi; YPR196W_mRNA; YPR196W; YPR196W.
DR   GeneID; 856326; -.
DR   KEGG; sce:YPR196W; -.
DR   SGD; S000006400; YPR196W.
DR   VEuPathDB; FungiDB:YPR196W; -.
DR   eggNOG; ENOG502S2FW; Eukaryota.
DR   GeneTree; ENSGT00940000176316; -.
DR   HOGENOM; CLU_046324_0_0_1; -.
DR   InParanoid; Q06595; -.
DR   OMA; MQAVLWK; -.
DR   BioCyc; YEAST:G3O-34317-MON; -.
DR   PRO; PR:Q06595; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q06595; protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISA:SGD.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR020448; Maltose_ferment_reg_DNA-bd.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   PRINTS; PR00054; FUNGALZNCYS.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..470
FT                   /note="Maltose fermentation regulatory protein YPR196W"
FT                   /id="PRO_0000257819"
FT   DNA_BIND        8..34
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   MOTIF           41..49
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   470 AA;  55077 MW;  11470323FF483F3B CRC64;
     MSIVRQSCDC CRVRRVKCDR NRPCDRCRQR NLRCTYLQPL RKRGPKSIGE SNLERAAEIQ
     MVTVNNNIMA APVMYKKVPK KVIDQCLRLY HDQLYVIWPM LSYDDLYKLL EENYEDCSTY
     WFLVSLSAAT LSDLHTKIEY KKGFFFAGEQ LCNLCMSSRR FFDDLSNSDI FRIMTYYCLH
     RCYAQFADTR TSYRLSCEAI GLIKIAGFHR EETYEFLPFG EQQLIRKVYY LLLMTERYYA
     VYIKCVTSLD TTISPPQPEI VTDSRLSLDS FLEVIKVFTV PGKYFYDALA TNSVNGSYTE
     DSLKRIWNEL HISSLDIEPY SYGYIDYLFS RHWVRTLAWK LVLNKKDMRM NFFSNTNATH
     IPVEIAKDML QDTLLTPIDL YDVHGPVIPM KALEIANALV DVVSKYDHNM KLEAWNILCD
     VSKFVFSLKH CNHKMFQRFS TKCQSALIDL PISRPLRLND DSKDEVDIIP