ID   YP216_YEAST             Reviewed;        1102 AA.
AC   Q08964; D6W3F4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Putative ISWI chromatin-remodeling complex subunit YPL216W;
GN   OrderedLocusNames=YPL216W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: May be required for the activity of an ISWI chromatin-
CC       remodeling complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063,
CC       ECO:0000255|PROSITE-ProRule:PRU00475}.
CC   -!- MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z73572; CAA97931.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11220.1; -; Genomic_DNA.
DR   PIR; S65235; S65235.
DR   RefSeq; NP_015108.1; NM_001184030.1.
DR   AlphaFoldDB; Q08964; -.
DR   SMR; Q08964; -.
DR   BioGRID; 35969; 81.
DR   DIP; DIP-3968N; -.
DR   MINT; Q08964; -.
DR   STRING; 4932.YPL216W; -.
DR   PaxDb; Q08964; -.
DR   PRIDE; Q08964; -.
DR   EnsemblFungi; YPL216W_mRNA; YPL216W; YPL216W.
DR   GeneID; 855885; -.
DR   KEGG; sce:YPL216W; -.
DR   SGD; S000006137; YPL216W.
DR   VEuPathDB; FungiDB:YPL216W; -.
DR   eggNOG; KOG1245; Eukaryota.
DR   GeneTree; ENSGT00940000176599; -.
DR   HOGENOM; CLU_265647_0_0_1; -.
DR   InParanoid; Q08964; -.
DR   BioCyc; YEAST:G3O-34105-MON; -.
DR   PRO; PR:Q08964; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q08964; protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR018501; DDT_dom.
DR   InterPro; IPR028941; WHIM2_dom.
DR   InterPro; IPR013136; WSTF_Acf1_Cbp146.
DR   Pfam; PF02791; DDT; 1.
DR   Pfam; PF10537; WAC_Acf1_DNA_bd; 1.
DR   Pfam; PF15613; WSD; 1.
DR   SMART; SM00571; DDT; 1.
DR   PROSITE; PS50827; DDT; 1.
DR   PROSITE; PS51136; WAC; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Coiled coil; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1102
FT                   /note="Putative ISWI chromatin-remodeling complex subunit
FT                   YPL216W"
FT                   /id="PRO_0000242161"
FT   DOMAIN          23..131
FT                   /note="WAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00475"
FT   DOMAIN          375..435
FT                   /note="DDT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT   REGION          271..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          673..743
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1102 AA;  128133 MW;  E457A8CE097255D6 CRC64;
     MVLLNRRKIQ PKEIGQSADS FSETPWVIKE SSERINDYDS DLKKLDFYKR DIFTCEISGK
     DGLSYFKALK SEEQHREKVR YLLPKELRKA IANFANFSPI RKVGHLVESA FQRFSNRFFI
     GDTVCLKTIQ KNALITYKEG EPNLVESPTI ENNVTLFLVK DVFQSNGMME SEKGEISAPK
     LSLYLITECL NRESKGAALI VGQNEIKRPE SHFSKFIIAC FLNEILIKVS NKEHAPWRVK
     QEYIERYDVN PKCSPNMIDY LPDRMNSSSS ELYTPLTIPP ESDVEPADWK ETSETSETSE
     TSLSKIKAID DEISVSFDHI YDNVNSLAYN DLKGTVDDKE LPFTGPSIPF ENISYLDSSL
     EYKNIDQKWF KECSQFPTER LLVVYQFLSF FGRFIGLSHF NFDQFLTTIK CTSPEALVDE
     YVKINFLKTY NSKGSFTNEK PRNEIYNQVT SSNVSQREKA NVFNADESQR IPSNFTRNQK
     MRKFITDKST EFVMYSIFKG KPLKNDDMEF QSYEKVNILY IDIVCSLMCL MTDNEPDWNC
     NLMDNWTEEK RKEEGNKTEI DIAIEKCLNY GDTSWVKLLH NKNFSNGNWL ICLLGILQQN
     THMIAYSDVA KCITKKILPL SMNFVNLGDE LWDNFRKRLS IKDKIDVLWV LVDFASNFSS
     YIKELVDKVP KLCNGIRLKL DSAKKEYIKL KRQLKTLTKN RVKLHSNVSM NRYGSDECKG
     KVNALKVKIA YLMEDIAFLE AKLIQSDIKR LEILGKDRNG NRYYWMDSNG SSSAISEKNE
     ELYNCCFLWV QGPSEADINF CLDVDVESLK KWELLAKAKG TAYATKEVFS IFRSTDGSYY
     QIAQGENFMI INSNGILMRP TIPAFIDKKI ISETPEKLLL SHHQWAFFND IEDIHMLVDR
     LDDLRENEGQ LKKALTSKMD RIEVSYKQQF KIKRRIECDE TFKKNHKLLK NNEFTFPELK
     RIETTCTSNG QHFSNMEKIS KKLSRTKNDL VLEAILKDVA HLGECERALL KKQQNLIYPL
     NFHFEQLRTI DLEFIVETKR KRQEDILTKL LNHQRYKHIS HVSGYGISSQ RVDKAAHLDV
     QGILEEIECQ LISRRREDEE RN