YP257_YEAST
ID YP257_YEAST Reviewed; 193 AA.
AC Q08974; D6W3B4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized membrane protein YPL257W;
GN OrderedLocusNames=YPL257W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=12829295; DOI=10.1016/s0378-1097(03)00384-7;
RA Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N.,
RA Sudimack D.W., Pathak R., Stone T.L., Polymenis M.;
RT "The budding index of Saccharomyces cerevisiae deletion strains identifies
RT genes important for cell cycle progression.";
RL FEMS Microbiol. Lett. 223:253-258(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: May be required for cell cycle progression.
CC {ECO:0000269|PubMed:12829295}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
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DR EMBL; Z73613; CAA97985.1; -; Genomic_DNA.
DR EMBL; AY692571; AAT92590.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11180.1; -; Genomic_DNA.
DR PIR; S65288; S65288.
DR RefSeq; NP_015066.1; NM_001184071.1.
DR AlphaFoldDB; Q08974; -.
DR BioGRID; 35906; 35.
DR DIP; DIP-5352N; -.
DR IntAct; Q08974; 3.
DR STRING; 4932.YPL257W; -.
DR PaxDb; Q08974; -.
DR TopDownProteomics; Q08974; -.
DR EnsemblFungi; YPL257W_mRNA; YPL257W; YPL257W.
DR GeneID; 855818; -.
DR KEGG; sce:YPL257W; -.
DR SGD; S000006178; YPL257W.
DR VEuPathDB; FungiDB:YPL257W; -.
DR HOGENOM; CLU_121576_0_0_1; -.
DR OMA; WGERACR; -.
DR BioCyc; YEAST:G3O-34142-MON; -.
DR PRO; PR:Q08974; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q08974; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR031427; DUF4668.
DR Pfam; PF15701; DUF4668; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..193
FT /note="Uncharacterized membrane protein YPL257W"
FT /id="PRO_0000242486"
FT TOPO_DOM 1..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 193 AA; 22197 MW; 9EFB6F4E1166160C CRC64;
MTAHANERIS DVSPSARGSS SESKYDKLCR VLFFIAITKS SFTPEHILYK HSIFTDKPIL
ADIVTFMYAA FVSIGWFLIW GERAYRTQEM GQPPMYSNIN YHLLSFKKRH PKKFTCALWL
VFFLAYTVLT VLIWLVQLIF RKGNVFQMLL QLIILDIAIA LVNVAIAFTF EIYLSQKAAI
EIRDEGLNNL DTA
