YP276_YEAST
ID YP276_YEAST Reviewed; 145 AA.
AC P0CF36; Q08987; Q08988;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Putative uncharacterized protein YPL276W;
GN OrderedLocusNames=YPL276W {ECO:0000312|SGD:S000006197}; ORFNames=P0323;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 93-145, AND CONFIRMATION OF STOP
RP CODON.
RC STRAIN=ATCC 200060 / W303, and ATCC 201388 / BY4741;
RX PubMed=11921099; DOI=10.1002/yea.856;
RA Overkamp K.M., Koetter P., van der Hoek R., Schoondermark-Stolk S.,
RA Luttik M.A.H., van Dijken J.P., Pronk J.T.;
RT "Functional analysis of structural genes for NAD(+)-dependent formate
RT dehydrogenase in Saccharomyces cerevisiae.";
RL Yeast 19:509-520(2002).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. FDH subfamily. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC functional protein. This is a truncated version of a second copy of
CC formate dehydrogenase in the yeast genome. Strains BY4741, S288c and
CC W303 have a stop codon in position 146, which disrupts the gene coding
CC for this protein and produces two ORFs YPL275W and YPL276W. Because of
CC that it is not part of the S.cerevisiae S288c complete/reference
CC proteome set. A contiguous sequence for formate dehydrogenase 2 can be
CC found in found in strain CEN.PK113-7D (AC P0CT22).
CC {ECO:0000305|PubMed:11921099, ECO:0000305|PubMed:24374639}.
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DR EMBL; Z73632; CAA98012.1; -; Genomic_DNA.
DR EMBL; AY558055; AAS56381.1; -; Genomic_DNA.
DR PIR; S65309; S65309.
DR AlphaFoldDB; P0CF36; -.
DR SMR; P0CF36; -.
DR SGD; S000006197; YPL276W.
DR VEuPathDB; FungiDB:YPL276W; -.
DR InParanoid; P0CF36; -.
DR GO; GO:0005829; C:cytosol; ISS:SGD.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IGI:SGD.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0042183; P:formate catabolic process; IGI:SGD.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR Pfam; PF00389; 2-Hacid_dh; 1.
PE 5: Uncertain;
FT CHAIN 1..145
FT /note="Putative uncharacterized protein YPL276W"
FT /id="PRO_0000393443"
FT BINDING 97
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P33160"
FT BINDING 121
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P33160"
SQ SEQUENCE 145 AA; 15936 MW; 0F0A487EF014AF07 CRC64;
MSKGKVLLVL YEGGKHAEEQ EKLLGCIENE LGIRNFIEEQ GYELVTTIDK DPEPTSTVDR
ELKDAEIVIT TPFFPAYISR NRIAEAPNLK LCVTAGVGSD HVDLEAANER KITVTEVTGS
NVVSVAEHVM ATILVLIRNY NGGHQ
