ID   YP52_SCHPO              Reviewed;         220 AA.
AC   B5BP46;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Putative glutathione S-transferase C460.02c;
DE            EC=2.5.1.18;
GN   ORFNames=SPBC460.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=18727152; DOI=10.1002/yea.1613;
RA   Sasaki M., Idiris A., Tada A., Kumagai H., Giga-Hama Y., Tohda H.;
RT   "The gap-filling sequence on the left arm of chromosome 2 in fission yeast
RT   Schizosaccharomyces pombe.";
RL   Yeast 25:673-679(2008).
CC   -!- FUNCTION: Involved in the oxidative stress response and detoxification.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + RX = a halide anion + an S-substituted
CC         glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:90779; EC=2.5.1.18;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; AB325691; BAG68902.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5BP46; -.
DR   SMR; B5BP46; -.
DR   STRING; 4896.SPBC460.02c.1; -.
DR   iPTMnet; B5BP46; -.
DR   MaxQB; B5BP46; -.
DR   PaxDb; B5BP46; -.
DR   EnsemblFungi; SPBC460.02c.1; SPBC460.02c.1:pep; SPBC460.02c.
DR   PomBase; SPBC460.02c; -.
DR   VEuPathDB; FungiDB:SPBC460.02c; -.
DR   eggNOG; KOG0867; Eukaryota.
DR   HOGENOM; CLU_011226_3_2_1; -.
DR   InParanoid; B5BP46; -.
DR   OMA; FECMAIA; -.
DR   PRO; PR:B5BP46; -.
DR   Proteomes; UP000002485; Chromosome II, gap-filling sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004364; F:glutathione transferase activity; ISM:PomBase.
DR   GO; GO:0002182; P:cytoplasmic translational elongation; ISO:PomBase.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Transferase.
FT   CHAIN           1..220
FT                   /note="Putative glutathione S-transferase C460.02c"
FT                   /id="PRO_0000415923"
FT   DOMAIN          1..81
FT                   /note="GST N-terminal"
FT   DOMAIN          89..216
FT                   /note="GST C-terminal"
SQ   SEQUENCE   220 AA;  25717 MW;  9BC90C709E47BC91 CRC64;
     MFLGTIYSFK TNTRTPCLLE LAKRLDLQVD LVETYHHKFP TDLAAKFPLQ KLPVFIGADG
     FELSEVIAIF KYFYEKGKHN DKEGLGPINE IEEAEMLKWM CFINFDIVTP QIVRPWVDMF
     RGSVPYEDKA FKESAARAID SLKIINELVK DRTYLVGDRF TLADLFFGSM LRRFFHSIID
     EKTRKELPHL TRYYVTMFHQ AKLEAYYPLE LPLTVTVPNN