YPD1_CANAL
ID YPD1_CANAL Reviewed; 184 AA.
AC Q59WC6; A0A1D8PE42; G1UAK5; Q9HGV5;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Phosphorelay intermediate protein YPD1;
GN Name=YPD1; OrderedLocusNames=CAALFM_C107240WA;
GN ORFNames=CaO19.11923, CaO19.4443;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=10923027;
RX DOI=10.1002/1097-0061(200008)16:11<1053::aid-yea598>3.0.co;2-h;
RA Calera J.A., Herman D., Calderone R.;
RT "Identification of YPD1, a gene of Candida albicans which encodes a two-
RT component phosphohistidine intermediate protein.";
RL Yeast 16:1053-1059(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP FUNCTION.
RX PubMed=17038117; DOI=10.1111/j.1365-2958.2006.05438.x;
RA Menon V., Li D., Chauhan N., Rajnarayanan R., Dubrovska A., West A.H.,
RA Calderone R.;
RT "Functional studies of the Ssk1p response regulator protein of Candida
RT albicans as determined by phenotypic analysis of receiver domain point
RT mutants.";
RL Mol. Microbiol. 62:997-1013(2006).
CC -!- FUNCTION: Phosphorelay intermediate protein that is part of the
CC bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which
CC controls activity of the HOG1 pathway and gene expression in response
CC to oxidative stress and probably to changes in the osmolarity of the
CC extracellular environment. Catalyzes the phosphoryl group transfer from
CC the membrane-bound histidine kinase SLN1 to two distinct response
CC regulators SSK1 and SKN7. {ECO:0000269|PubMed:17038117}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YPD1 family. {ECO:0000305}.
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DR EMBL; AF213247; AAG01679.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26376.1; -; Genomic_DNA.
DR RefSeq; XP_713887.1; XM_708794.1.
DR AlphaFoldDB; Q59WC6; -.
DR SMR; Q59WC6; -.
DR STRING; 237561.Q59WC6; -.
DR GeneID; 3644458; -.
DR KEGG; cal:CAALFM_C107240WA; -.
DR CGD; CAL0000174022; YPD1.
DR VEuPathDB; FungiDB:C1_07240W_A; -.
DR eggNOG; KOG4747; Eukaryota.
DR HOGENOM; CLU_085158_2_0_1; -.
DR InParanoid; Q59WC6; -.
DR OMA; LVEWSVF; -.
DR OrthoDB; 1484583at2759; -.
DR PRO; PR:Q59WC6; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:CGD.
DR GO; GO:0005634; C:nucleus; IDA:CGD.
DR GO; GO:0009927; F:histidine phosphotransfer kinase activity; IBA:GO_Central.
DR GO; GO:0043424; F:protein histidine kinase binding; IBA:GO_Central.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IGI:CGD.
DR GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IMP:CGD.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR CDD; cd00088; HPT; 1.
DR Gene3D; 1.20.120.160; -; 1.
DR InterPro; IPR045871; AHP1-5/YPD1.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR PANTHER; PTHR28242; PTHR28242; 1.
DR Pfam; PF01627; Hpt; 1.
DR SMART; SM00073; HPT; 1.
DR SUPFAM; SSF47226; SSF47226; 1.
DR PROSITE; PS50894; HPT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Stress response;
KW Two-component regulatory system.
FT CHAIN 1..184
FT /note="Phosphorelay intermediate protein YPD1"
FT /id="PRO_0000425804"
FT DOMAIN 30..125
FT /note="HPt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00110"
FT REGION 120..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 69
FT /note="Phosphohistidine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 184 AA; 20564 MW; 3C5CAE6424A18CF1 CRC64;
MSEDKLQKLQ DSGLVDWAVF SEIVTMDEDE EGFSKSLVEV FVSQVEETFE EIDKYLKEKN
LEKLSSSGHF LKGSAAALGL TKISNQCERI QNYGHKINFD NFQLEDIKTK GDSAVSAENV
AVNDGETNPE NGSNGNETSN NKTNTSNIPD ESSDDFWIAL IEDALAKARD GFDQSRRALD
EYYE
