ID   YPDB_SHIFL              Reviewed;         244 AA.
AC   P0AE41; P77742;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Transcriptional regulatory protein YpdB {ECO:0000250|UniProtKB:P0AE39};
GN   Name=ypdB; OrderedLocusNames=SF2444.2, S2585;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system YpdA/YpdB. YpdB
CC       regulates expression of yhjX by binding to its promoter region.
CC       {ECO:0000250|UniProtKB:P0AE39}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by YpdA. {ECO:0000250}.
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DR   EMBL; AE005674; AAN43957.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17767.1; -; Genomic_DNA.
DR   RefSeq; NP_708250.2; NC_004337.2.
DR   RefSeq; WP_001295458.1; NZ_WPGN01000006.1.
DR   AlphaFoldDB; P0AE41; -.
DR   SMR; P0AE41; -.
DR   STRING; 198214.SF2447; -.
DR   EnsemblBacteria; AAN43957; AAN43957; SF2447.
DR   EnsemblBacteria; AAP17767; AAP17767; S2585.
DR   GeneID; 1027211; -.
DR   GeneID; 67416782; -.
DR   KEGG; sfl:SF2447; -.
DR   KEGG; sfx:S2585; -.
DR   PATRIC; fig|198214.7.peg.2923; -.
DR   HOGENOM; CLU_000445_14_1_6; -.
DR   OMA; DIHMPDF; -.
DR   OrthoDB; 1958442at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..244
FT                   /note="Transcriptional regulatory protein YpdB"
FT                   /id="PRO_0000081383"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          139..244
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   244 AA;  28721 MW;  679EA97A44F1260B CRC64;
     MKVIIVEDEF LAQQELSWLI KEHSQMEIVG TFDDGLDVLK FLQHNRVDAI FLDINIPSLD
     GVLLAQNISQ FAHKPFIVFI TAWKEHAVEA FELEAFDYIL KPYQESRITG MLQKLEAAWQ
     QQQTSSTPAA TVTRENDTIN LVKDERIIVT PINDIYYAEA HEKMTFVYTR RESYVMPMNI
     TEFCSKLPPS HFFRCHRSFC VNLNKIREIE PWFNNTYILR LKDLDFEVPV SRSKVKEFRQ
     LMHL