ID   YPEB_BACSU              Reviewed;         450 AA.
AC   P38490; P40774;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Sporulation protein YpeB;
DE   AltName: Full=PSPA12;
GN   Name=ypeB; Synonyms=joeB, yzuA; OrderedLocusNames=BSU22920;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA   Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA   Serror P.;
RT   "Sequence analysis of the Bacillus subtilis chromosome region between the
RT   serA and kdg loci cloned in a yeast artificial chromosome.";
RL   Microbiology 142:2005-2016(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-331.
RC   STRAIN=168;
RX   PubMed=8830707; DOI=10.1128/jb.178.20.6059-6063.1996;
RA   Moriyama R., Hattori A., Miyata S., Kudoh S., Makino S.;
RT   "A gene (sleB) encoding a spore cortex-lytic enzyme from Bacillus subtilis
RT   and response of the enzyme to L-alanine-mediated germination.";
RL   J. Bacteriol. 178:6059-6063(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-450.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RA   Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA   Serror P.;
RL   Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
RX   PubMed=3145906; DOI=10.1016/0378-1119(88)90207-7;
RA   Smith H., de Jong A., Bron S., Venema G.;
RT   "Characterization of signal-sequence-coding regions selected from the
RT   Bacillus subtilis chromosome.";
RL   Gene 70:351-361(1988).
RN   [6]
RP   CHARACTERIZATION.
RC   STRAIN=168;
RX   PubMed=10658652; DOI=10.1099/00221287-146-1-57;
RA   Boland F.M., Atrih A., Chirakkal H., Foster S.J., Moir A.;
RT   "Complete spore-cortex hydrolysis during germination of Bacillus subtilis
RT   168 requires SleB and YpeB.";
RL   Microbiology 146:57-64(2000).
RN   [7]
RP   CHARACTERIZATION.
RC   STRAIN=168;
RX   PubMed=12177332; DOI=10.1099/00221287-148-8-2383;
RA   Chirakkal H., O'Rourke M., Atrih A., Foster S.J., Moir A.;
RT   "Analysis of spore cortex lytic enzymes and related proteins in Bacillus
RT   subtilis endospore germination.";
RL   Microbiology 148:2383-2392(2002).
CC   -!- FUNCTION: Required for spore cortex hydrolysis during germination.
CC       Appears to be required for either expression, localization, activation
CC       or function of SleB.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the forespore during sporulation.
CC   -!- INDUCTION: Expression is sigma G-dependent.
CC   -!- SIMILARITY: Belongs to the YpeB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA22820.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L47648; AAC83958.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14208.1; -; Genomic_DNA.
DR   EMBL; D79978; BAA11474.1; -; Genomic_DNA.
DR   EMBL; U11687; AAA85146.1; -; Genomic_DNA.
DR   EMBL; M22904; AAA22820.1; ALT_FRAME; Genomic_DNA.
DR   PIR; E69934; E69934.
DR   RefSeq; NP_390173.1; NC_000964.3.
DR   RefSeq; WP_003230547.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P38490; -.
DR   SMR; P38490; -.
DR   STRING; 224308.BSU22920; -.
DR   PaxDb; P38490; -.
DR   PRIDE; P38490; -.
DR   EnsemblBacteria; CAB14208; CAB14208; BSU_22920.
DR   GeneID; 938981; -.
DR   KEGG; bsu:BSU22920; -.
DR   PATRIC; fig|224308.179.peg.2499; -.
DR   eggNOG; COG2959; Bacteria.
DR   OMA; WRITSEA; -.
DR   BioCyc; BSUB:BSU22920-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0009847; P:spore germination; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR025711; PepSY.
DR   InterPro; IPR014239; Spore_YpeB.
DR   Pfam; PF03413; PepSY; 1.
DR   Pfam; PF14620; YPEB; 1.
DR   TIGRFAMs; TIGR02889; spore_YpeB; 1.
PE   1: Evidence at protein level;
KW   Germination; Reference proteome; Sporulation.
FT   CHAIN           1..450
FT                   /note="Sporulation protein YpeB"
FT                   /id="PRO_0000066395"
SQ   SEQUENCE   450 AA;  51185 MW;  8B4A7E479C088E6B CRC64;
     MIRGILIAVL GIAIVGTGYW GYKEHQEKDA VLLHAENNYQ RAFHELTYQV DQLHDKIGTT
     LAMNSQKSLS PALIDVWRIT SEAHNSVSQL PLTLMPFNKT EELLSKIGDF SYKTSVRDLD
     QKPLDKNEYT SLNKLYQQSE DIQNELRHVQ HLVMSKNLRW MDVEMALASD EKQSDNTIIN
     SFKTVEKNVG AFSTGTDLGP SFTSTKKEEK GFSHLKGKQI SEQEAKQIAE RFAPDDNYSI
     KVVKSGKKTN RDVYSISMKD PDHKAVIYMD ITKKGGHPVY LIQNREVKDQ KISLNDGSNR
     ALAFLKKNGF ETDDLEIDES AQYDKIGVFS YVPVENKVRM YPEAIRMKVA LDDGEVVGFS
     ARDFLTSHRK RTIPKPAITE AEAKSKLNKN VQVRETRLAL ITNELGQEVL CYEMLGTIEN
     DTFRMYINAK DGSEEKVEKL KNAEPIYKDL