YPEL1_HUMAN
ID YPEL1_HUMAN Reviewed; 119 AA.
AC O60688; Q65ZA1; Q6GLI6;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein yippee-like 1;
GN Name=YPEL1; ORFNames=FKSG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15556292; DOI=10.1016/j.gene.2004.06.014;
RA Hosono K., Sasaki T., Minoshima S., Shimizu N.;
RT "Identification and characterization of a novel gene family YPEL in a wide
RT spectrum of eukaryotic species.";
RL Gene 340:31-43(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hu G., Hui L.;
RT "Human unknown cDNA, complete cds.";
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang Y.-G.;
RT "Cloning and characterization of FKSG3, a novel gene related to DiGeorge
RT syndrome.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in epithelioid conversion of fibroblasts.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; AB098734; BAD51375.1; -; mRNA.
DR EMBL; AB098735; BAD51376.1; -; mRNA.
DR EMBL; AF060862; AAC15461.1; -; mRNA.
DR EMBL; AF305069; AAL09353.1; -; mRNA.
DR EMBL; CR456376; CAG30262.1; -; mRNA.
DR EMBL; CR933630; CAI45937.1; -; Transcribed_RNA.
DR EMBL; BC034486; AAH34486.1; -; mRNA.
DR EMBL; BC074501; AAH74501.1; -; mRNA.
DR CCDS; CCDS13794.1; -.
DR PIR; T50835; T50835.
DR RefSeq; NP_037445.1; NM_013313.4.
DR AlphaFoldDB; O60688; -.
DR BioGRID; 118923; 15.
DR IntAct; O60688; 6.
DR STRING; 9606.ENSP00000342832; -.
DR BioMuta; YPEL1; -.
DR MassIVE; O60688; -.
DR PaxDb; O60688; -.
DR PeptideAtlas; O60688; -.
DR PRIDE; O60688; -.
DR ProteomicsDB; 49529; -.
DR Antibodypedia; 45067; 68 antibodies from 21 providers.
DR DNASU; 29799; -.
DR Ensembl; ENST00000339468.8; ENSP00000342832.3; ENSG00000100027.17.
DR GeneID; 29799; -.
DR KEGG; hsa:29799; -.
DR MANE-Select; ENST00000339468.8; ENSP00000342832.3; NM_013313.5; NP_037445.1.
DR UCSC; uc002zvl.4; human.
DR CTD; 29799; -.
DR DisGeNET; 29799; -.
DR GeneCards; YPEL1; -.
DR HGNC; HGNC:12845; YPEL1.
DR HPA; ENSG00000100027; Tissue enhanced (testis).
DR MIM; 608082; gene.
DR neXtProt; NX_O60688; -.
DR OpenTargets; ENSG00000100027; -.
DR PharmGKB; PA37436; -.
DR VEuPathDB; HostDB:ENSG00000100027; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000161453; -.
DR HOGENOM; CLU_043857_5_2_1; -.
DR InParanoid; O60688; -.
DR OMA; HLAFKGH; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; O60688; -.
DR TreeFam; TF313936; -.
DR PathwayCommons; O60688; -.
DR SignaLink; O60688; -.
DR BioGRID-ORCS; 29799; 114 hits in 1084 CRISPR screens.
DR ChiTaRS; YPEL1; human.
DR GenomeRNAi; 29799; -.
DR Pharos; O60688; Tbio.
DR PRO; PR:O60688; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O60688; protein.
DR Bgee; ENSG00000100027; Expressed in left testis and 147 other tissues.
DR ExpressionAtlas; O60688; baseline and differential.
DR Genevisible; O60688; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Zinc.
FT CHAIN 1..119
FT /note="Protein yippee-like 1"
FT /id="PRO_0000212381"
FT DOMAIN 19..116
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT MOTIF 99..104
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT CONFLICT 108
FT /note="E -> D (in Ref. 6; AAH74501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 119 AA; 13575 MW; E91C058FA8C6D81F CRC64;
MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGWE
