YPEL1_MOUSE
ID YPEL1_MOUSE Reviewed; 118 AA.
AC Q9ESC7;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein yippee-like 1;
DE AltName: Full=DGL-1;
DE AltName: Full=Mdgl-1;
GN Name=Ypel1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J; TISSUE=Branchial arch region;
RX PubMed=11473580; DOI=10.1046/j.1365-2443.2001.00445.x;
RA Farlie P.G., Reid C.J., Wilcox S., Peeters J., Reed G., Newgreen D.F.;
RT "Ypel1: a novel nuclear protein that induces an epithelial-like morphology
RT in fibroblasts.";
RL Genes Cells 6:619-629(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in epithelioid conversion of fibroblasts.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11473580}.
CC -!- DEVELOPMENTAL STAGE: At 9.5 dpc, expressed throughout the ventral
CC mesoderm of the trunk and head. At 10.5 dpc, maintained in the ventral
CC aspect of the axial tissues; detected in the branchial clefts,
CC branchial arches, in the heart and in the cranial mesenchyme underlying
CC the mid-brain. No expression in the dorsal part of the embryo, in the
CC somatopleure nor in the splanchnopleure. At 11.0 dpc, expressed in the
CC branchial arches in the mesenchyme underlying the ectoderm, but not the
CC endoderm. {ECO:0000269|PubMed:11473580}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; AF190624; AAG17143.1; -; mRNA.
DR EMBL; AK005955; BAB24338.1; -; mRNA.
DR EMBL; AK006505; BAB24624.1; -; mRNA.
DR EMBL; AK006858; BAB24767.1; -; mRNA.
DR EMBL; AK014931; BAB29625.1; -; mRNA.
DR EMBL; AK015752; BAB29957.1; -; mRNA.
DR EMBL; AK018910; BAB31479.1; -; mRNA.
DR EMBL; AK019819; BAB31864.1; -; mRNA.
DR EMBL; AK076063; BAC36157.1; -; mRNA.
DR CCDS; CCDS37268.1; -.
DR RefSeq; NP_001277976.1; NM_001291047.1.
DR RefSeq; NP_001277982.1; NM_001291053.1.
DR RefSeq; NP_075738.1; NM_023249.6.
DR AlphaFoldDB; Q9ESC7; -.
DR STRING; 10090.ENSMUSP00000039760; -.
DR MaxQB; Q9ESC7; -.
DR PaxDb; Q9ESC7; -.
DR PRIDE; Q9ESC7; -.
DR ProteomicsDB; 275228; -.
DR Antibodypedia; 45067; 68 antibodies from 21 providers.
DR DNASU; 106369; -.
DR Ensembl; ENSMUST00000035682; ENSMUSP00000039760; ENSMUSG00000022773.
DR Ensembl; ENSMUST00000231394; ENSMUSP00000156275; ENSMUSG00000022773.
DR GeneID; 106369; -.
DR KEGG; mmu:106369; -.
DR UCSC; uc007yju.2; mouse.
DR CTD; 29799; -.
DR MGI; MGI:1913303; Ypel1.
DR VEuPathDB; HostDB:ENSMUSG00000022773; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000161453; -.
DR HOGENOM; CLU_043857_5_2_1; -.
DR InParanoid; Q9ESC7; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; Q9ESC7; -.
DR TreeFam; TF313936; -.
DR BioGRID-ORCS; 106369; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ypel1; mouse.
DR PRO; PR:Q9ESC7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9ESC7; protein.
DR Bgee; ENSMUSG00000022773; Expressed in spermatocyte and 167 other tissues.
DR ExpressionAtlas; Q9ESC7; baseline and differential.
DR Genevisible; Q9ESC7; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Zinc.
FT CHAIN 1..118
FT /note="Protein yippee-like 1"
FT /id="PRO_0000212382"
FT DOMAIN 19..116
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT MOTIF 99..104
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ SEQUENCE 118 AA; 13468 MW; 85E211D126A61A1F CRC64;
MVKMTKSKTF QAYLPHCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGW
