YPEL2_HUMAN
ID YPEL2_HUMAN Reviewed; 119 AA.
AC Q96QA6; A0PK16; A2RUG4; Q65ZA0; Q8N3W2;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein yippee-like 2;
GN Name=YPEL2; ORFNames=FKSG4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15556292; DOI=10.1016/j.gene.2004.06.014;
RA Hosono K., Sasaki T., Minoshima S., Shimizu N.;
RT "Identification and characterization of a novel gene family YPEL in a wide
RT spectrum of eukaryotic species.";
RL Gene 340:31-43(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang Y.-G.;
RT "Cloning and characterization of FKSG4, a novel gene related to DiGeorge
RT syndrome.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH FAM168B.
RX PubMed=22771904; DOI=10.1016/j.febslet.2012.06.043;
RA Mishra M., Lee S., Lin M.K., Yamashita T., Heese K.;
RT "Characterizing the neurite outgrowth inhibitory effect of Mani.";
RL FEBS Lett. 586:3018-3023(2012).
CC -!- SUBUNIT: May interact with FAM168B.
CC -!- INTERACTION:
CC Q96QA6; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-6658719, EBI-79165;
CC Q96QA6; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-6658719, EBI-747035;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Detected in fetal and adult
CC kidney, heart, liver, lung and skeletal muscle.
CC {ECO:0000269|PubMed:15556292}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB098736; BAD51377.1; -; Genomic_DNA.
DR EMBL; AF305195; AAL09354.1; -; mRNA.
DR EMBL; BC127924; AAI27925.1; -; mRNA.
DR EMBL; BC132884; AAI32885.1; -; mRNA.
DR EMBL; BC132886; AAI32887.1; -; mRNA.
DR CCDS; CCDS32695.1; -.
DR RefSeq; NP_001005404.1; NM_001005404.3.
DR RefSeq; XP_016880110.1; XM_017024621.1.
DR AlphaFoldDB; Q96QA6; -.
DR BioGRID; 132675; 5.
DR IntAct; Q96QA6; 5.
DR MINT; Q96QA6; -.
DR STRING; 9606.ENSP00000312272; -.
DR GlyGen; Q96QA6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96QA6; -.
DR PhosphoSitePlus; Q96QA6; -.
DR BioMuta; YPEL2; -.
DR DMDM; 27805781; -.
DR MassIVE; Q96QA6; -.
DR PaxDb; Q96QA6; -.
DR PeptideAtlas; Q96QA6; -.
DR PRIDE; Q96QA6; -.
DR ProteomicsDB; 77847; -.
DR Antibodypedia; 56995; 26 antibodies from 15 providers.
DR DNASU; 388403; -.
DR Ensembl; ENST00000312655.9; ENSP00000312272.4; ENSG00000175155.11.
DR Ensembl; ENST00000585166.1; ENSP00000464285.1; ENSG00000175155.11.
DR GeneID; 388403; -.
DR KEGG; hsa:388403; -.
DR MANE-Select; ENST00000312655.9; ENSP00000312272.4; NM_001005404.4; NP_001005404.1.
DR UCSC; uc002ixm.2; human.
DR CTD; 388403; -.
DR DisGeNET; 388403; -.
DR GeneCards; YPEL2; -.
DR HGNC; HGNC:18326; YPEL2.
DR HPA; ENSG00000175155; Tissue enhanced (retina).
DR MIM; 609723; gene.
DR neXtProt; NX_Q96QA6; -.
DR OpenTargets; ENSG00000175155; -.
DR PharmGKB; PA134978522; -.
DR VEuPathDB; HostDB:ENSG00000175155; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000159010; -.
DR HOGENOM; CLU_043857_5_2_1; -.
DR InParanoid; Q96QA6; -.
DR OMA; GQHGKAF; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; Q96QA6; -.
DR TreeFam; TF313936; -.
DR PathwayCommons; Q96QA6; -.
DR SignaLink; Q96QA6; -.
DR BioGRID-ORCS; 388403; 12 hits in 1077 CRISPR screens.
DR ChiTaRS; YPEL2; human.
DR GenomeRNAi; 388403; -.
DR Pharos; Q96QA6; Tdark.
DR PRO; PR:Q96QA6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96QA6; protein.
DR Bgee; ENSG00000175155; Expressed in pancreatic ductal cell and 193 other tissues.
DR ExpressionAtlas; Q96QA6; baseline and differential.
DR Genevisible; Q96QA6; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Zinc.
FT CHAIN 1..119
FT /note="Protein yippee-like 2"
FT /id="PRO_0000212385"
FT DOMAIN 19..116
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ SEQUENCE 119 AA; 13577 MW; 5904018C67E1A2D2 CRC64;
MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKYIIELA HMIKDNGWD
