ID   YPEL2_MOUSE             Reviewed;         119 AA.
AC   Q65Z95;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Protein yippee-like 2;
GN   Name=Ypel2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15556292; DOI=10.1016/j.gene.2004.06.014;
RA   Hosono K., Sasaki T., Minoshima S., Shimizu N.;
RT   "Identification and characterization of a novel gene family YPEL in a wide
RT   spectrum of eukaryotic species.";
RL   Gene 340:31-43(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBUNIT: May interact with FAM168B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in testis, heart, brain, spleen, lung and
CC       liver. {ECO:0000269|PubMed:15556292}.
CC   -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR   EMBL; AB098741; BAD51382.1; -; mRNA.
DR   EMBL; AL596111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS25205.1; -.
DR   RefSeq; NP_001005341.1; NM_001005341.3.
DR   AlphaFoldDB; Q65Z95; -.
DR   BioGRID; 218983; 1.
DR   STRING; 10090.ENSMUSP00000018571; -.
DR   PhosphoSitePlus; Q65Z95; -.
DR   MaxQB; Q65Z95; -.
DR   PaxDb; Q65Z95; -.
DR   PRIDE; Q65Z95; -.
DR   ProteomicsDB; 299633; -.
DR   Antibodypedia; 56995; 26 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000018571; ENSMUSP00000018571; ENSMUSG00000018427.
DR   GeneID; 77864; -.
DR   KEGG; mmu:77864; -.
DR   UCSC; uc007ktd.1; mouse.
DR   CTD; 388403; -.
DR   MGI; MGI:1925114; Ypel2.
DR   VEuPathDB; HostDB:ENSMUSG00000018427; -.
DR   eggNOG; KOG3399; Eukaryota.
DR   GeneTree; ENSGT00940000159010; -.
DR   HOGENOM; CLU_043857_5_2_1; -.
DR   InParanoid; Q65Z95; -.
DR   OMA; GQHGKAF; -.
DR   OrthoDB; 1431042at2759; -.
DR   PhylomeDB; Q65Z95; -.
DR   TreeFam; TF313936; -.
DR   BioGRID-ORCS; 77864; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Ypel2; mouse.
DR   PRO; PR:Q65Z95; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q65Z95; protein.
DR   Bgee; ENSMUSG00000018427; Expressed in cumulus cell and 229 other tissues.
DR   ExpressionAtlas; Q65Z95; baseline and differential.
DR   Genevisible; Q65Z95; MM.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR034751; Yippee.
DR   InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR   InterPro; IPR039058; Yippee_fam.
DR   PANTHER; PTHR13848; PTHR13848; 1.
DR   Pfam; PF03226; Yippee-Mis18; 1.
DR   PROSITE; PS51792; YIPPEE; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..119
FT                   /note="Protein yippee-like 2"
FT                   /id="PRO_0000212386"
FT   DOMAIN          19..116
FT                   /note="Yippee"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         79
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         82
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ   SEQUENCE   119 AA;  13577 MW;  5904018C67E1A2D2 CRC64;
     MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
     PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKYIIELA HMIKDNGWD