YPEL3_HUMAN
ID YPEL3_HUMAN Reviewed; 119 AA.
AC P61236; Q65Z99; Q86VK6; Q9BSJ4; Q9CQB6;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein yippee-like 3;
GN Name=YPEL3; ORFNames=FKSG5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15556292; DOI=10.1016/j.gene.2004.06.014;
RA Hosono K., Sasaki T., Minoshima S., Shimizu N.;
RT "Identification and characterization of a novel gene family YPEL in a wide
RT spectrum of eukaryotic species.";
RL Gene 340:31-43(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wang Y.-G.;
RT "Cloning and characterization of FKSG5, a novel gene related to DiGeorge
RT syndrome.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in proliferation and apoptosis in myeloid precursor
CC cells. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P61236-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P61236-2; Sequence=VSP_037276;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15556292}.
CC -!- PTM: Probably ubiquitinated leading to its degradation by the
CC proteasome. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW79925.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB098737; BAD51378.1; -; Genomic_DNA.
DR EMBL; AF305622; AAL09365.1; -; mRNA.
DR EMBL; AC012645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471238; EAW79925.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC005009; AAH05009.3; -; mRNA.
DR EMBL; BC050664; AAH50664.2; -; mRNA.
DR CCDS; CCDS42147.1; -. [P61236-2]
DR CCDS; CCDS45459.1; -. [P61236-1]
DR RefSeq; NP_001138996.1; NM_001145524.1. [P61236-1]
DR RefSeq; NP_113665.3; NM_031477.4. [P61236-2]
DR AlphaFoldDB; P61236; -.
DR BioGRID; 123740; 135.
DR IntAct; P61236; 4.
DR STRING; 9606.ENSP00000381821; -.
DR BioMuta; YPEL3; -.
DR DMDM; 47117782; -.
DR MassIVE; P61236; -.
DR PaxDb; P61236; -.
DR PeptideAtlas; P61236; -.
DR PRIDE; P61236; -.
DR ProteomicsDB; 57279; -. [P61236-1]
DR ProteomicsDB; 57280; -. [P61236-2]
DR Antibodypedia; 27015; 81 antibodies from 25 providers.
DR DNASU; 83719; -.
DR Ensembl; ENST00000398838.8; ENSP00000381818.4; ENSG00000090238.12. [P61236-1]
DR Ensembl; ENST00000398841.6; ENSP00000381821.1; ENSG00000090238.12. [P61236-2]
DR Ensembl; ENST00000563788.5; ENSP00000457976.1; ENSG00000090238.12. [P61236-1]
DR Ensembl; ENST00000566595.5; ENSP00000456427.1; ENSG00000090238.12. [P61236-1]
DR GeneID; 83719; -.
DR KEGG; hsa:83719; -.
DR MANE-Select; ENST00000398841.6; ENSP00000381821.1; NM_031477.5; NP_113665.3. [P61236-2]
DR UCSC; uc002dwl.3; human. [P61236-1]
DR CTD; 83719; -.
DR DisGeNET; 83719; -.
DR GeneCards; YPEL3; -.
DR HGNC; HGNC:18327; YPEL3.
DR HPA; ENSG00000090238; Low tissue specificity.
DR MIM; 609724; gene.
DR neXtProt; NX_P61236; -.
DR OpenTargets; ENSG00000090238; -.
DR PharmGKB; PA134985092; -.
DR VEuPathDB; HostDB:ENSG00000090238; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000161514; -.
DR HOGENOM; CLU_043857_5_2_1; -.
DR InParanoid; P61236; -.
DR OMA; CCCGQII; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; P61236; -.
DR TreeFam; TF313936; -.
DR PathwayCommons; P61236; -.
DR SignaLink; P61236; -.
DR BioGRID-ORCS; 83719; 31 hits in 1079 CRISPR screens.
DR GenomeRNAi; 83719; -.
DR Pharos; P61236; Tbio.
DR PRO; PR:P61236; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P61236; protein.
DR Bgee; ENSG00000090238; Expressed in right hemisphere of cerebellum and 182 other tissues.
DR ExpressionAtlas; P61236; baseline and differential.
DR Genevisible; P61236; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:2000774; P:positive regulation of cellular senescence; IDA:HGNC.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome;
KW Ubl conjugation; Zinc.
FT CHAIN 1..119
FT /note="Protein yippee-like 3"
FT /id="PRO_0000212389"
FT DOMAIN 19..116
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT VAR_SEQ 1
FT /note="M -> MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAM (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_037276"
SQ SEQUENCE 119 AA; 13608 MW; A35E852DEB1FFBB4 CRC64;
MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL FNSVVNVGCG
PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY KEGKYIIELN HMIKDNGWD
