YPEL4_HUMAN
ID YPEL4_HUMAN Reviewed; 127 AA.
AC Q96NS1; B3KW92; Q2M3U7; Q65Z98;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein yippee-like 4;
GN Name=YPEL4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15556292; DOI=10.1016/j.gene.2004.06.014;
RA Hosono K., Sasaki T., Minoshima S., Shimizu N.;
RT "Identification and characterization of a novel gene family YPEL in a wide
RT spectrum of eukaryotic species.";
RL Gene 340:31-43(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Detected adult brain, lung,
CC colon, small intestine and ovary, and in fetal brain, lung, liver and
CC spleen. {ECO:0000269|PubMed:15556292}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; AB098738; BAD51379.1; -; Genomic_DNA.
DR EMBL; AK054775; BAB70805.1; -; mRNA.
DR EMBL; AK124577; BAG54054.1; -; mRNA.
DR EMBL; CH471076; EAW73765.1; -; Genomic_DNA.
DR EMBL; BC104781; AAI04782.1; -; mRNA.
DR EMBL; BC112119; AAI12120.1; -; mRNA.
DR CCDS; CCDS7963.1; -.
DR RefSeq; NP_659445.1; NM_145008.2.
DR RefSeq; XP_016872807.1; XM_017017318.1.
DR AlphaFoldDB; Q96NS1; -.
DR BioGRID; 128552; 2.
DR STRING; 9606.ENSP00000432648; -.
DR iPTMnet; Q96NS1; -.
DR PhosphoSitePlus; Q96NS1; -.
DR BioMuta; YPEL4; -.
DR DMDM; 27805780; -.
DR MassIVE; Q96NS1; -.
DR PaxDb; Q96NS1; -.
DR PeptideAtlas; Q96NS1; -.
DR PRIDE; Q96NS1; -.
DR ProteomicsDB; 77550; -.
DR Antibodypedia; 65159; 25 antibodies from 14 providers.
DR DNASU; 219539; -.
DR Ensembl; ENST00000300022.8; ENSP00000300022.3; ENSG00000166793.13.
DR Ensembl; ENST00000524669.5; ENSP00000432648.1; ENSG00000166793.13.
DR Ensembl; ENST00000534711.5; ENSP00000432165.1; ENSG00000166793.13.
DR GeneID; 219539; -.
DR KEGG; hsa:219539; -.
DR MANE-Select; ENST00000300022.8; ENSP00000300022.3; NM_145008.3; NP_659445.1.
DR UCSC; uc001nkv.5; human.
DR CTD; 219539; -.
DR DisGeNET; 219539; -.
DR GeneCards; YPEL4; -.
DR HGNC; HGNC:18328; YPEL4.
DR HPA; ENSG00000166793; Tissue enhanced (brain).
DR MIM; 609725; gene.
DR neXtProt; NX_Q96NS1; -.
DR OpenTargets; ENSG00000166793; -.
DR PharmGKB; PA134991609; -.
DR VEuPathDB; HostDB:ENSG00000166793; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000161443; -.
DR HOGENOM; CLU_043857_5_2_1; -.
DR InParanoid; Q96NS1; -.
DR OMA; PVMPSCE; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; Q96NS1; -.
DR TreeFam; TF313936; -.
DR PathwayCommons; Q96NS1; -.
DR BioGRID-ORCS; 219539; 13 hits in 1075 CRISPR screens.
DR ChiTaRS; YPEL4; human.
DR GenomeRNAi; 219539; -.
DR Pharos; Q96NS1; Tdark.
DR PRO; PR:Q96NS1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96NS1; protein.
DR Bgee; ENSG00000166793; Expressed in right hemisphere of cerebellum and 127 other tissues.
DR ExpressionAtlas; Q96NS1; baseline and differential.
DR Genevisible; Q96NS1; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc.
FT CHAIN 1..127
FT /note="Protein yippee-like 4"
FT /id="PRO_0000212392"
FT DOMAIN 27..124
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 31
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 90
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT MOD_RES 92
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5XID5"
FT MOD_RES 93
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5XID5"
FT MOD_RES 98
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q5XID5"
SQ SEQUENCE 127 AA; 14301 MW; BF9894D7D03883B3 CRC64;
MPSCDPGPGP ACLPTKTFRS YLPRCHRTYS CVHCRAHLAK HDELISKSFQ GSHGRAYLFN
SVVNVGCGPA EQRLLLTGLH SVADIFCESC KTTLGWKYEQ AFETSQKYKE GKYIIEMSHM
VKDNGWD
