ID   YPEL4_RAT               Reviewed;         127 AA.
AC   Q5XID5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein yippee-like 4;
GN   Name=Ypel4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92; THR-93 AND TYR-98, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR   EMBL; BC083749; AAH83749.1; -; mRNA.
DR   RefSeq; NP_001019540.1; NM_001024369.1.
DR   AlphaFoldDB; Q5XID5; -.
DR   STRING; 10116.ENSRNOP00000009762; -.
DR   iPTMnet; Q5XID5; -.
DR   PhosphoSitePlus; Q5XID5; -.
DR   PaxDb; Q5XID5; -.
DR   PRIDE; Q5XID5; -.
DR   GeneID; 502643; -.
DR   KEGG; rno:502643; -.
DR   UCSC; RGD:1560142; rat.
DR   CTD; 219539; -.
DR   RGD; 1560142; Ypel4.
DR   eggNOG; KOG3399; Eukaryota.
DR   HOGENOM; CLU_043857_5_2_1; -.
DR   InParanoid; Q5XID5; -.
DR   OMA; PVMPSCE; -.
DR   OrthoDB; 1431042at2759; -.
DR   PhylomeDB; Q5XID5; -.
DR   TreeFam; TF313936; -.
DR   PRO; PR:Q5XID5; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000060130; Expressed in cerebellum and 18 other tissues.
DR   Genevisible; Q5XID5; RN.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR034751; Yippee.
DR   InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR   InterPro; IPR039058; Yippee_fam.
DR   PANTHER; PTHR13848; PTHR13848; 1.
DR   Pfam; PF03226; Yippee-Mis18; 1.
DR   PROSITE; PS51792; YIPPEE; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc.
FT   CHAIN           1..127
FT                   /note="Protein yippee-like 4"
FT                   /id="PRO_0000212394"
FT   DOMAIN          27..124
FT                   /note="Yippee"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         31
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         34
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         90
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   MOD_RES         92
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
FT   MOD_RES         93
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
FT   MOD_RES         98
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
SQ   SEQUENCE   127 AA;  14315 MW;  D99894D7D6388121 CRC64;
     MPSCDPGPAP ACLPTKTFRS YLPRCHRTYS CVHCRAHLAK HDELISKSFQ GSHGRAYLFN
     SVVNVGCGPA EQRLLLTGLH SVADIFCESC KTTLGWKYEQ AFETSQKYKE GKYIIEMSHM
     VKDNGWD