YPF01_PLAF7
ID YPF01_PLAF7 Reviewed; 2068 AA.
AC Q8IDG7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Uncharacterized protein PF13_0277;
GN ORFNames=PF13_0277;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|EMBL:CAD52654.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 1040-1066, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000305}.
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DR EMBL; AL844509; CAD52654.1; -; Genomic_DNA.
DR RefSeq; XP_001350245.1; XM_001350209.1.
DR AlphaFoldDB; Q8IDG7; -.
DR BioGRID; 1209497; 1.
DR PRIDE; Q8IDG7; -.
DR EnsemblProtists; CAD52654; CAD52654; PF3D7_1353300.
DR GeneID; 814242; -.
DR KEGG; pfa:PF3D7_1353300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1353300; -.
DR HOGENOM; CLU_232867_0_0_1; -.
DR InParanoid; Q8IDG7; -.
DR OMA; IMNIFFK; -.
DR PhylomeDB; Q8IDG7; -.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Membrane; Merozoite; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..2068
FT /note="Uncharacterized protein PF13_0277"
FT /id="PRO_0000361761"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1890..1910
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 975..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1021
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2068 AA; 248260 MW; 7183900AF2E74014 CRC64;
MDFFIIIFIL LLSFFFFDYN FCSRGLVFYI GNKSLKLLKK CNNLEKVYRS TIYLIFPFLQ
HIFVHIFYYY IEKKKEYLNN LIFEQSKEHY DIKGQKEFEA CNFKKEDIFN YIIETSIKIK
NYVYNKALHI FFFIVEYTNI YENINLNCHI NTREVLNNNN FGVVIIDYYL PNTSIKKKKK
KKKKDQTYNY INDSEKIDLY DLVNIKQEKK IKFVLIDNKW KHILGLGKIE DPNVQHLYLQ
DTVLIQYLQF SWIFKNHFFK KLYNDRDVST HNYYEIKKNS MQQNDRDGVK EQYKKTCLGE
EELIVDGNTC NNNHLNDHVN IKDEEYFNNK NYMNDQEEII IRSLKKWNIN KENVCSNKEE
NFNLITNNDK LMENTIYKND NKDLYIETQK MKEDHVYNNS INLKKTKINE IEQNNLNTQN
NNCYSNKEKY YINQEKKKQQ LKYIKNENMI RDKLKMQLNR WKYKNIKGII VILPEIFYNY
INMNEMENKI PIYYFLKKDI KIDTFTVIAK LLGYICIHIH ININFGFSIP FIFKSKTTNI
LNISNNFNLH MNKNLFNIYN ENGTSNIKGT HTNISSDDKK LKCSKHISKQ DIKNNINLCH
KSVSNLNDHE KENKNKQDKM NIYSYINDHI NIYNNDNNDN NSIHNNLYNK QNDNIKDTIN
YMDQNDKNNC HDMFLNNNYN EQSNEYHNHQ QCVNNINDEN RYQNYAHNNN NNNYNYIHTD
YTNSKLNSIV ENKFNMDDNY TFLFSTPFSF FSDNYNDLNI AMNHFKAIFK NYNFVFLCFN
DGTNIMLNYF LEKIYKKKKN KTPGGMTTLI STAGVAENIK NTFNLYNTNA YKCHINNYKK
KHVHDTKGDT YDNEKKKHSK LYPINKSEED KKSKCTLHKA NNKSNIMSLF FGEKKKKKYL
EHEQMNQSQR FKKITKKWDI HKILSDIKGN DKSSFINQDK KINERKYNEI DKNDSDDSNA
SYDDEKILSH VVKEQMHSGE DEKEELGEPK EKGSKSCQEE EEQDEEEEDE DEEEEEDQGV
NNYDNYVDGV DRDVENYDNY IDDVDRDVEN YDKGIANVDH HLNDVHKDLD DHKKVEEVIA
DIEKEDKNVE RKNVNLKGAQ NKTEYQQELV KKLDTDQNIN IDKKTMNQIN NSEFSNNVEN
VQDKQKNKIK KEEMFTKNTK KNMKIKMKDN KNNDMGKLRN IKEKLKKKKM ETLLNLSKLN
IFHKNSEQIS ENYIKEEDNL YRNDYNTNES KIWSIYESHV SNDPRGSAST YKGNSSINKF
ANMSLSNFAS FIKKHKNNNS NHSLVGSFKD NLEIKEIISK TNCEKNLNKY IDLNKENVME
IDMKEFVEPN IKHDVEKNVY KDINKNTNNE IVKTHNIVDE KNLNTQIQKY VNYDNEKNIK
EDVERNVENN CERHEMKNSE IKKIKLNILE KFRKKEIRKC DNMDDAPRIS NKFRYSFFKI
RNRFKHNFNA CDNKTNQEKK NMERDKMMIN SFIKNKNAMV SDANSTSTAD SNFDDYGKKH
TKEICILINF SYNNMFDIFN YPDDFIETKK RKFSIVHKFF YSLNIFFNSF STLIKQRYFF
RCTSELSNFL KRSLFYDFYN NLLCKISTDD QDRNNFLLDI NNSSNEYDVH LKRLSDITYI
CNSEKPDKYR DLLENKSNIT SIYDDKKNVS RTNMSTYINK DMECTWHDNN QNKKSEKNFE
NIKNENIQEI DKIDLKYNNI NNNNNNNNIS ENNNIRSNIG NEIYNNVSDM NKKNSSNNVN
NPMEYNKDYT YNNSSIRDND NNINVEIYKK NSLNTIEYFE NNLSFFNKIH KMNKKKDEYK
CDEKLYCKTK NIKSNNELYD VKNSYKLNNN NNNNNMIFNE TYNNNTFFKN IYSDSFESKI
RVYFNIKSLY EKWKIYFEDK QIDISIQDKF LYNLSFIYNV YNYLILIYIY TYYNEESYLA
FCNNQKFYQF IEKIHCYFNE KKNNHILYKN VRNSESFNTS IIPRFLNYHD YKLLKVFFFM
LQNSSNKFIS KNIHLFNFPV VFIFSSDSKN FNFNHFDIIK ISKNNNIIYL LYKRGNEGLF
LSGLKPYIWI YRVLFDFVES LFLSSFDN
