ID   YPF06_PLAF7             Reviewed;         584 AA.
AC   Q9U0M8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Uncharacterized protein PFA0635c {ECO:0000312|EMBL:CAB63564.1};
GN   ORFNames=PFA0635c;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000312|EMBL:CAB63564.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000305}
RP   SYNTHESIS OF 438-473, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; AL844501; CAB63564.1; -; Genomic_DNA.
DR   RefSeq; XP_001351056.1; XM_001351020.1.
DR   AlphaFoldDB; Q9U0M8; -.
DR   SMR; Q9U0M8; -.
DR   IntAct; Q9U0M8; 4.
DR   STRING; 5833.PFA0635c; -.
DR   PRIDE; Q9U0M8; -.
DR   EnsemblProtists; CAB63564; CAB63564; PF3D7_0113300.
DR   GeneID; 813262; -.
DR   KEGG; pfa:PF3D7_0113300; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0113300; -.
DR   HOGENOM; CLU_467349_0_0_1; -.
DR   OMA; CIYESLH; -.
DR   PhylomeDB; Q9U0M8; -.
DR   Proteomes; UP000001450; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Merozoite; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..584
FT                   /note="Uncharacterized protein PFA0635c"
FT                   /id="PRO_0000371503"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          184..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          267..319
FT                   /evidence="ECO:0000255"
FT   COILED          436..477
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        205..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  70985 MW;  6E06F4C58A08F838 CRC64;
     MKNIKNMKNI KSEGFIFFVL VFFICIIFGC IYESLHEGPY KKTLNSLHES TKYRHFNKIR
     LLTEYKDTLQ IKVEQKSLRD YVNNDRYNNV NTNDYTSYKD KGEQFNDTIC VVDKKKENVT
     INNEEECNKN FYQYLQYLEH NNKQDNKYEE TNYFLQGNDK HIDSEHNGIN KMYKETIHKT
     LTSDVSTENS YTHNNSRDDE PQNGKRTYNN QSNNNLPYDN SSYNISPYHG PNNNVPYNKS
     NNFEQCNTQD NKHCNDLDTY HTCYGPDNYP QKYDNYRQEC DNYRQECDNY RQEYDNYPQK
     YDNYRQECDN YRQEYDNYPH GFDNYPRGFD NYPHGYDNHP HRPHIYPHGF DNHPHRPHMY
     PHNFPMRNES VGGPYYRPPH IIERSNYYKN PKKAPHNMML PCDTMKDNKS ICDEQNFQRE
     LEKIIKKNNL QNGNIRDNHD TRINDYNKRL TEYNKRLTEY NKRLTEYTKR LNEHYKRNGY
     NIQNRQNSIE RAQSNDVVLY GHNFQNAFRY KQNTRSYYPH VNSNEATHHQ KTMYFTQQNN
     YSREEYPIKS EQHLYHVKSK RLEKKLYDYQ NGTNPVTNFL ERHF