YPF08_PLAF7
ID YPF08_PLAF7 Reviewed; 2588 AA.
AC O96185; A0A143ZWL6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Uncharacterized protein PF3D7_0210200;
GN ORFNames=PF3D7_0210200 {ECO:0000312|EMBL:CZT98116.1}, PFB0460c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=9804551; DOI=10.1126/science.282.5391.1126;
RA Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L.,
RA Koonin E.V., Shallom S.J., Mason T., Yu K., Fujii C., Pederson J., Shen K.,
RA Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S.L.,
RA Zhou L., Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M.,
RA Adams M.D., Venter J.C., Hoffman S.L.;
RT "Chromosome 2 sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Science 282:1126-1132(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 616-645, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; LN999943; CZT98116.1; -; Genomic_DNA.
DR PIR; D71614; D71614.
DR RefSeq; XP_001349610.1; XM_001349574.1.
DR AlphaFoldDB; O96185; -.
DR SMR; O96185; -.
DR STRING; 5833.PFB0460c; -.
DR SwissPalm; O96185; -.
DR PRIDE; O96185; -.
DR EnsemblProtists; CZT98116; CZT98116; PF3D7_0210200.
DR VEuPathDB; PlasmoDB:PF3D7_0210200; -.
DR InParanoid; O96185; -.
DR OMA; FSNDHTH; -.
DR Proteomes; UP000001450; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR InterPro; IPR040163; RP1/RP1L1/DCX.
DR PANTHER; PTHR23005; PTHR23005; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Reference proteome.
FT CHAIN 1..2588
FT /note="Uncharacterized protein PF3D7_0210200"
FT /id="PRO_0000388761"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1631..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1820..1856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2317..2342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2415..2437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 413..452
FT /evidence="ECO:0000255"
FT COMPBIAS 19..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2317..2333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2417..2437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2588 AA; 310026 MW; 40A9C0BE94716570 CRC64;
MSFKNNEKYM DEENDQESDD EFFKVKRKPQ INVDAEEDED NNNNNNNNNN NSNISNHMNE
FDLEEEDEDD YEDENYIVGE TIEIDESKLK NEKIEEDIFN ENNLLHGIKT RELLEQEILI
LFSNMLKKET ILCKDIKSGS NDPMDEISLF KDDMVDDKEL KDFEKSSLKI KNKEVYNFIY
NKMNLHIKEN KKKDEKEKKN KIHNNDENNN MIYYKNIDKT HYILDNNVVH ILNDINTYLK
RERDYMNRKF GTYIDSTYKN PMYVTLYIFN NDILKDIILQ VIDIIRNDFD HAIYKDIDEN
QLIKNLIILI NHLTTRPSKE WFDYWKRHMP TFNDKKSEYN VYKYLQLQKS DRRILYDTLK
NDIYIKELQK RSDILDQYQK GLQSLKCLLA NKNFLTMLNE FRYNTQLFID ADYREIEENE
KVMEMQRREN ELLEEKKRLK QELESYHDDS STDDDSSADE QQDERREVLT HNDPINKKDD
PINKNDDPIN KNDDPINKND DNINKNDDNI NKNDDNICNS NDHTHNSNDH THNSNDHTHN
SNDHTHNSND HTHFSNDHTH FSNDHTHFSN DHTHFSNDHT HNSNDHTHNS KNHAHFSNEV
DKTNDYKYHS EKKKKNNVIR SKMYNIKKRI SKINDELHEL SNFFLIDKTK REKLMFEYNE
NVFLVRNILT QVLGIRNKTD NRDINLNNVH YAILQNILDK HGCLHLIIDE MRDLFEKEIK
KYEEESNIYI PYIKQNTMKQ IWEYIRLFYN IICYIDPIDL VKSLTYQKST HIIKKEKKKT
KTDMDNNNNN NNNNNNDNNN IMMNQKFLNN YHNKKHLNTS DNVNNMKTNN LRNYNKDINL
KNVGKDMNKR KSMAQQQNKR KSNYINIKQK NLMITHLSRI NPLLAKSKVR KPNEEKHLKK
RKRKFIERKN LIDHYEIFSF EDFSFNMFSE DRLFNKYNIL DIFDYSNLYK IQDFLNNIIG
INEEFESIYE NDDNFHYSLK VFLNICIKDL RRCINEFYNF QWDIKIILNM HAWIVTYYTN
LYIYENRKRF YNSRNKNKNN KEHQMNRDDE RKCTKEYTNQ NEGEMKYDHN RKREDEQKNH
KYCNINCNIN CNINCNKNCN KNCNINYNNG DNNVYDNNVY DNNDDYNDDY NDDYNDDYND
DYNDVNQNTY VKHNNQNENS SLFISRIQMV LGLQMYIGDN SIHSEFLCDT FQRVIREEKM
MKNSSQVILC CLRCLYSDLN LLDIHSLSTD ENVKSICKTS LDNLLKRNIL TTLSWILQNF
KILSHEKHIF IYSLKCSLLI INLLAKLGGT TYIIKEKKNI HNDSHDDNND DSVNDSNDDT
NNVNVNVNVN DYYDDDDDDN NNNNRIDKKK KHKKKKYNNE PMEKIDVSDL VEEIFNGKIV
NICMHILENF KRNSLYINDL IITYFEHLIK HKNNEYNFLI FFDIKYFLIF KDIINDPEAY
NNPHYYWIPC FFENIIACFF KIWKSNYFIV NELLFTKDIN KNNSNLLNEK YLLSIFSNYN
EGNDPFIFQQ LNEGIYINDI FINLNNKKRL ESLEWSNEDI ENLKFYFKQF KHMHNFLPFI
SEMLNKSSNV VKNQLIYLNY LDKRGKVIYD DQYESDNMIS SSSSSSSSSS SSSSLSSSSS
LSCVSYLSEA QNSNNKSNDS LKMSYSKKKK QHTNEHMNHH QNYPMRKTKQ PLLYIIYKLK
KLNYNNNNNN NNNNNNNDDN TKDQPKLTVN EINCNVDTVL EEINVNLKSL YELKKLSKNK
IFNNKALAFD IPLSISPDLL EHHYFKKLLK HIGFLYNQNV DEWILNENLD IDIFKKTIDK
FEQLYIMDIQ KLKKKLSSHK LNVQTNDQGE RQDERNIDHE DEPVSSNTED DHEENDYFTY
DHIDERDHKK CDDKKYSDNT NETYDDQKCD DNTNETYDNE KCDEAINNKH MDEQELHLRS
PSIKTKGTLK LLKLMYEFFI SNDDECRLFF NNLINTIKEK CIIIFEKLKK CKLDHDILYK
DTTNNYYDHT SHPVQICFED YKIYLNNNEK SILKGRCKHK NILEELLEIL GLYISNVPCL
IISKHIKEEE FYERITTIND HKTLSLNDLN MIITTKEKEI KEKKKKKKEE RKPSAHQKFA
FIKSICEYLN YNYIIRNTYK SEQNTNNHND NNIIYNNTYS KLKDTYFGDD KLLTALYDKL
NIWNNRRKKK NDDMVLEIPI PQFVGSMCNV GTSEGEHEQK LDESKNIYTK EYNNDEKFLK
SHINCQDDTQ KISSLVIHIG ICLKGEYHDE SILKWTCEQI HREWMKIMLK LFYNILYDTT
YNVIGKLFKE YKNIKEILND QSSDFLDMYK SDKKKKKKKK ELDDVEKEGQ PKMGVGNDDN
INGDKNIYDD NINGDDNING DKNIYDDDKN IYDDDDNING DKNIYDGNYK ISYSKEYEHI
HMDEKKEVEK EYHIYDNNNN NDNNNDNNND NNNNSHTLAF QNRTQGETTF TNINNITNDI
CEKGNKYTSN VNNINNINEM TCKESVEVNE IIQKTNKRKF HNIELKEHYC YDLFKKRKLE
NTYRNTYKKN RKIIINCLLT NKNIFQYKEH DIVNKVKQIF IKAKHMATNG DLRNRWKSRE
DVKKILLL
