ID   YPF09_PLAF7             Reviewed;         781 AA.
AC   Q8I5Z5; A0A144A3J2;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Uncharacterized protein PF3D7_1205000;
GN   ORFNames=PF3D7_1205000, PFL0250w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 263-292, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; LN999947; CZT99212.1; -; Genomic_DNA.
DR   RefSeq; XP_001350459.1; XM_001350423.1.
DR   AlphaFoldDB; Q8I5Z5; -.
DR   SMR; Q8I5Z5; -.
DR   STRING; 5833.PFL0250w; -.
DR   PRIDE; Q8I5Z5; -.
DR   EnsemblProtists; CZT99212; CZT99212; PF3D7_1205000.
DR   GeneID; 811103; -.
DR   KEGG; pfa:PF3D7_1205000; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1205000; -.
DR   HOGENOM; CLU_019922_0_0_1; -.
DR   InParanoid; Q8I5Z5; -.
DR   OMA; EIFFFKS; -.
DR   Proteomes; UP000001450; Chromosome 12.
DR   GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Membrane; Merozoite; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..781
FT                   /note="Uncharacterized protein PF3D7_1205000"
FT                   /id="PRO_0000388762"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  91839 MW;  870B0C2201300C4A CRC64;
     MSYNDGSEEE NDSNTYIHDE KKKKKKKNNK NAYALINEVN YSQEDEQEVI HNTNSEDETS
     NRKGNGCVYS LSDQNVEDHI ISLPEYLDLI NNNNNNSNSY KMKKEKKKKK KKKKNQTDEE
     NMKNKKDHIY QNNITNQQND IKNDYKKINH HNMNNKKNKI FCQDDQNIFN INHTFQIHET
     VQNNLIIPPS ETCLASDIIQ PSDTTQSNTY LNEATASQND DNNNEDSSNE MGMFKKIFYR
     IKKIIVDKKG TPITNENDVD NDMCELNVME NNMNNIHSNN NNISTHMDDV IEDESNEEVF
     VINRNTDGYI NTRENINVST HVTRQMINLS ELNPNDLLCN VSEYEEGQNI NSLWNDNNNN
     NNNNNNNFLV GSLNALHPIN HNLRNENIHN DNINNTHINY DNNNSYESPI HILSFSFKNI
     YNKISSYINE HITHIKEKIK KYWLERVQEA NTQLNSPRPV HTRNTTNINT NININEDEND
     DPSCVQILFF MGLICKFPIL WIIGSIVFCI TPSEHRKTKT WSLVNTFFAL LSIIYFITTT
     NFRLRKPTFF VILEQNVENK NTYPKGILKY NNMIHHKHII IDQSSLHKWK DLHTNKVYKT
     SENYFLNRNF LSSQKPDSNI LLSDTIYKLL NRIQVTVTFG KGNIYSSDNI EKIKPFFQNL
     RINMDPISYD KLTMTDEDIP DDFFGSGLRC ERTYNNHNQN INEPQQNKEK EKWYLFWKEE
     EINNSHNKNI YNISIPVGEI FFFKSEYNCR IAFLYPKSIL YDQNDIPSNF VEIQKIIIKP
     F