ID   YPF10_PLAF7             Reviewed;         781 AA.
AC   Q8I5G1; A0A143ZZZ3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Uncharacterized protein PF3D7_1225600;
GN   ORFNames=PF3D7_1225600, PFL1235c;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 618-647, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; LN999947; CZT99415.1; -; Genomic_DNA.
DR   RefSeq; XP_001350653.1; XM_001350617.1.
DR   AlphaFoldDB; Q8I5G1; -.
DR   SMR; Q8I5G1; -.
DR   BioGRID; 1206670; 1.
DR   IntAct; Q8I5G1; 1.
DR   STRING; 5833.PFL1235c; -.
DR   PRIDE; Q8I5G1; -.
DR   EnsemblProtists; CZT99415; CZT99415; PF3D7_1225600.
DR   VEuPathDB; PlasmoDB:PF3D7_1225600; -.
DR   HOGENOM; CLU_328050_0_0_1; -.
DR   InParanoid; Q8I5G1; -.
DR   OMA; KYMTYEI; -.
DR   PhylomeDB; Q8I5G1; -.
DR   Proteomes; UP000001450; Chromosome 12.
PE   1: Evidence at protein level;
KW   Coiled coil; Merozoite; Reference proteome.
FT   CHAIN           1..781
FT                   /note="Uncharacterized protein PF3D7_1225600"
FT                   /id="PRO_0000388763"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          616..655
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        11..25
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  93047 MW;  E1E3C691869E7729 CRC64;
     MKKDEKNNMD ESLEEYDEEN YTSELDDLPE YERELILAKR HEEYMKKKHR RMLLKNLHID
     EKSKGNIHDD TNKSIETSNK RKGKLNNKKL KLKKKLYESD EEEENDKNDK NDDDQYDNTY
     QSDEDRKKSN NKKKEQSKKI KGDNESYNID SISYVKYKKG KIKILEDDDE KNHEDEKKKT
     DIIDHVSVTD DSYTDSSYKN KKKSKYKKGD TNQTDKTSKK NKNDKTNKTN KTNVSIKTKK
     HREDYSDDSM DDYHSTSSYE HEKSSDVHYN KKEKKIQLKV ISEESHLDNT KNKTGKGLNK
     ILIEKEKKKK KKDLHIVDSV HKNKEDGKNV ITDIFEKNEK INKDKELELP QTPERLIHLY
     KEEKKIKMDI YNYMTYDIIT YFQLKKTFLL DMCEHVHFSY HVIGHMIKII DISKLNKVTN
     QDVQNTNNKK KIDTANENKK KIFFITNVIK SEPYFSTDRN TNIKFEVAHL ENLAHSKFFK
     KIKNIMYQNK KISMDEIKSN EYYETYICDM NNISDQKFTI DEYNHIKLFS IDLDVLKTFH
     LFLKEKNEDL KNFRYTEKQL QDLFEKKKQK SFYEIYTNNK SIDNLPITRI TVQREICSIQ
     REIDKLNFDK KKTNVNDTYT LSKLNNQINE LTKKINILRG NLDKARKNHA AMKSNDQFAQ
     EKNMTKEKSR TNIKSTQKDD ATNKFLGVKE MDISYFSKQI YDEKTNFNNM LSSKFINLPL
     DVHHKVVHHF LLGTIQNNDA VFYDDPSHKI KKELDAEIDK LLGLHGNRHI TLFDDIKKNY
     E