YPF14_PLAF7
ID YPF14_PLAF7 Reviewed; 1745 AA.
AC O96160; A0A143ZXZ0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Uncharacterized protein PF3D7_0207100;
GN ORFNames=PF3D7_0207100, PFB0315w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=9804551; DOI=10.1126/science.282.5391.1126;
RA Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L.,
RA Koonin E.V., Shallom S.J., Mason T., Yu K., Fujii C., Pederson J., Shen K.,
RA Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S.L.,
RA Zhou L., Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M.,
RA Adams M.D., Venter J.C., Hoffman S.L.;
RT "Chromosome 2 sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Science 282:1126-1132(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 1597-1643, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; LN999943; CZT98084.1; -; Genomic_DNA.
DR RefSeq; XP_001349581.2; XM_001349545.2.
DR AlphaFoldDB; O96160; -.
DR SMR; O96160; -.
DR STRING; 5833.PFB0315w; -.
DR PRIDE; O96160; -.
DR EnsemblProtists; CZT98084; CZT98084; PF3D7_0207100.
DR GeneID; 812663; -.
DR KEGG; pfa:PF3D7_0207100; -.
DR VEuPathDB; PlasmoDB:PF3D7_0207100; -.
DR HOGENOM; CLU_239575_0_0_1; -.
DR InParanoid; O96160; -.
DR OMA; CHSSDNQ; -.
DR PhylomeDB; O96160; -.
DR Proteomes; UP000001450; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24365; PTHR24365; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Reference proteome.
FT CHAIN 1..1745
FT /note="Uncharacterized protein PF3D7_0207100"
FT /id="PRO_0000388767"
FT REGION 522..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1080..1110
FT /evidence="ECO:0000255"
FT COMPBIAS 522..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..608
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1745 AA; 207845 MW; 2F55435AA1A6D186 CRC64;
MDSDKYKKFY VYNHGFTKQP FYERNLNDKG IHLKELKRLE RVDEPRLYNN VDKIPNKKEI
IYNNIKSNNI QVRVNQNNNE EKKKEEANYT CVNNKYVTLK NKVHVNKYVN NSNINKIKIV
PIIKCSNYKI KNNPISHLKS NYENKFVKLS NFSNIKNGCS HKDNVINETM DQHKSEQLNN
DNIKKLLYDY CIFREDTIKT KTNISYNKMN SFKDNEENIN YMDNNNIKSN SSSYCSYSNK
INQNNVNHTH LKTEFLNEKN SHTQNEQSIP LLDGLQNNHN SATKFHNNIY DNNNSLVNYK
SDKGIDLHNK MMKIETDKNG IITLEKKKHD EKYYNNIFLN PLNDNSNNVV ITTCDNKESY
RNSTSDMINK IFEKMMNEKK NILKMKNFND VIKKKITMAK EKILNSNSTI NMKKVSFYNS
KDEDLFNEKE NSYKYGVKRE NQEDINVIKN NMKRNNINID NNDNINIIKN DSVSKNIHIN
NKKKRDDDFP FNNSAGLLLD FDLCKRKVLE ILKNVQSSKK KNKILTNHNH SSDNQNCHSS
DNQNCHSSDN QNCHSSDNQN CHSSDNQNCD SNACNKKDEE KKRKKKKIKK KNKMKNKSNN
KSKNKRETKS KKISNNNNND NMNNQCDNMG DQRINNENMD KQNVNIQNEG NGFNNNKNNN
DLLNVYISPN MINHSLSSTC EKKNKEDNKM NDNKFLNSSS KMKIPEISTN NSNEKIVNVS
NDEMLVYHNL TVLNVKEQGG VTEESSCIKR TYFVDQFYDS YNMRNEKITD DNMQVEDIYN
VKENIKRTLK GDGHDDVKTN MLSEDNSYAS GLWGNEINFI SNNENCLNSY DISCDEKYIP
NEEEQDEELC SNNILVKDIE EKKMCGKLFF EEICVFRINE KNEHGHENLR KNNHNDDTHK
MYSSYENIQN INKQSTNPFC KKDEMEKSQG TNLFYDNYIN SVDITKLELN KNCYQHINYE
VQNLIKKENS YAAEMNVGLV FRKYIPILIN LSCNYLLIKK NEKNVITCIS YTNIIDVKIV
KKSKKNKERF LFKIVYVFKK KEQKTEKNVT LLFRANLMEI FEKIKGRVDY CIIPNEDDKN
IQLQDKKKKK GKKKKELQEE KMKKKKKTQE YVDIETVYEY VIEKYKRVHV LYLGRLLQIV
EKLFKKYILK YSFHKLRIFY EYKIEMEKLK KNYIHCIYDI SDKLEFLIKK KMQHYFNHII
INSYESSFIN YQIKTNDMLY NLLLKEKSAY QNHLGKNYIL ILYKVLLSMY KKKMAIYFRS
FVYNNIKVSK KKNAFAYTLT RVNSILVLYE RRIKSFIFSK LKFNYDNVSY FCFTMYKIYL
RRILFGYLRI RDNRINIKNV IEKNVYRLVK LISKISDNHK YNAFLKLQKY VYEQNEKKNK
MICDNLIYAN NELCNNLDKI AIEKGINQID CLIKFKRKEC LMKYFYTLKG PQINTERFYY
CIRYCSIFSF VLNKIIQKKV QHIFFQFVLK TLQRNNKNRL THAIKLLQVL VQKKEKKSVI
DVLQLYDKYP YIFQYKDLTK IEVFVICVQN FVTLYNRKLL LNFLLKLHYL KYQEQFMKTY
NGIGSIYKFV HVLDKKLMNT IRESFRVILQ NDKFLREKMN MKMEQMDMKM EKIDVNMDQM
DVKMEQMDVK MEQMDVKMKR MNKKKSKQIH VNYNNKAYSS SSPSPMLRYN KYKDMSSNSA
SLIKKYPFLI YNSEISPDCT TMADDKLSLP SNESVTHIFS YAYEDMDKIK KKIYDFNNKM
SNVDL
