YPF16_PLAF7
ID YPF16_PLAF7 Reviewed; 3459 AA.
AC Q8IBP1; A0A143ZWQ6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Uncharacterized membrane protein {ECO:0000305};
GN ORFNames=PF07_0086, PF3D7_0721000;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000312|Proteomes:UP000001450};
RN [1] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 779-832, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844506; CZT62677.1; -; Genomic_DNA.
DR RefSeq; XP_001349112.1; XM_001349076.1.
DR BioGRID; 1209987; 11.
DR IntAct; Q8IBP1; 9.
DR STRING; 5833.PF07_0086; -.
DR PRIDE; Q8IBP1; -.
DR EnsemblProtists; CZT62677; CZT62677; PF3D7_0721000.
DR VEuPathDB; PlasmoDB:PF3D7_0721000; -.
DR HOGENOM; CLU_224933_0_0_1; -.
DR InParanoid; Q8IBP1; -.
DR OMA; MRMRYYD; -.
DR Proteomes; UP000001450; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR InterPro; IPR038841; PF07_0086.
DR PANTHER; PTHR34740; PTHR34740; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..3459
FT /note="Uncharacterized membrane protein"
FT /id="PRO_0000388769"
FT TRANSMEM 1059..1079
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2059..2079
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2197..2217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 3229..3249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 3296..3316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 158..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1711..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2582..2644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2776..2835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 771..851
FT /evidence="ECO:0000255"
FT COILED 2785..2820
FT /evidence="ECO:0000255"
FT COMPBIAS 158..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..439
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2592..2636
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2777..2835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3459 AA; 420421 MW; 80C5082D09306D75 CRC64;
MVIDNEEKKK KWEYATDEYK TCSNNIDEDI LKDDKDVSYF EKVKSSDNVL KYDECSPLKE
KDTSYKGEHI KRGQFCKNKN NIYSDDDNNN IYNDDDNNNI YNDDDNNIYS CNNSYVSTHF
GNTKRSDDMN NAENKKKKNE KDLFYDKVDE ILNRQSDNDD DWIFNEDDEK KNKNNDGNDN
RYDYNDLQNN NNNDNNKYDY NFYDDEKKNK NNDGDDNKYD YNHLQNNNNN KYDYNFDDDE
KKKSHTPFDF YQEERQNKAY FLNIHTLNFE AHMLHALLKK NKYRLTKYNT NMNNMIYKYL
YLYKKKKSLK YKHLKEQSYN NYTKHKTYNY HHTNEKEKKK NTHVDKQKIY VDDNKGNVSP
EQVIHNKIEN MEKDDKGKFN KTDQTNKLLN IDYYNKNNKY GYITPDNDDG DDYNDDNDND
DNYNDDNYND DNYNDDNYND DNYNDEKKKK KNNLMDVHFL YMEYFIRKKK LTELTNIYNK
YIYNKDNLLY LKKWYLKNVY ILNSKGYDES NIRISDPKKI YEYNNINNNC SDIPGGENSD
TSYYFSPPSI KTYCLNNYFI CLLSKNNEII VIGYKFINIH NLIFFKENNN IDDFFFKTEG
PININFNYYK YPHYAVIKND LWKNIKNIKN IHINDKNKLC VNTSNCVYVF EIFLSNSKVK
YKYLYNYIEK GTFLNKENNI SSSLHIKEKK LLYFTPYNII YLNNNKNIFN SSITITKDIK
FKYKILNTSF YKNNIYMVIS YFNKITVFKN EAIYFVLQYD RNGDVVSEQE VNEKKKGENE
MNKEVNKMNE EVNKMNEEVN KMNEEVNKMN KEVNKMDEEV NKMNKEVNKM NKESNEMNKE
ANEMNKDEEN EKYENHNYNY ENNICINTNG YDKKGEDEEK YNLKDDYISY IPFLGILENN
HFCAAYGKTL TVFEYVSKVV IKYKYILNHS IYFFKSCDNN IIIIYDKYKL YVYQIMLKGD
SNFCILLLYE KKMNNVTSRV ISEGYNIYES YDGFIQVNKK NVKVNKNDKI ANFMFSLFNQ
DIVLNEQNSK KDVSFFYINL IYIYVLNNDK VDIIVINSLI YMIYLFFTYK KYDLLLMFIL
HLYNGDVCVL SDFSLKEEEK KIQIQKLLFF FFETQMRDII QNYKDYKEKQ IHNNDYFIKY
RGDQNEGRRQ EKVLNNKDNN DKNDKNDKND KNDKNDKNEK NEKNDYDKRS EYISYEYTPL
RDITYTVSSL SSTLSCSLSG DEKKEEDSIM SLSKEDDRYH KYIIDDQDSY NLYRHYNNTN
HYEYIKNKKE VILKDEEEDI YINNKIINKE CIEELIHLCY LSIELSIKFN INLYEYTFHL
FKIYNIENVY FYICEPYIIN KKICLTHHSL IYNLVQYFKR FYSIFCLYDD TYYDLFLFFC
TLLTSKGGDE IIKGHKGIIP TQGDKNETDE GNKNETDEGD KNETDEGDKN ETDEGNKNET
EEIYKNETDE GNKNETEEIY KNDNDDDNYD DDYYHHYGEH HHYDSIMNNG YLTKFIFLLK
IQNKREHYEL NYPHNHNTVP YKKKEKMDNM YHSNLMICED KSKEYINEEL ITFDYYFINK
YLNIKKNFKQ IKKIYCFICI INKFCKFFEN INLEKNLENI ISLLPLHISS YLYNKHNEDK
TTICEFFISY MIRKKNIFFF QFCIDNNIKN EMFPIYIPMY IFNNFYQTHF FLYYLYCVIF
KKQFSIHMDT YVNEKRHMVY IKDMYVLKKK QKKKGNNQKQ NHNYNDDINN KENNNNNNVP
LHRICIDDSS YYDKVFFVYS PLLYEKEQNY GINKNIVTLI EYMCKRYDKK CLHIKEEKDI
LSGLFFKELN VIEGNYMPRF EENKNKNDKI KDDNYGNNDK RCGKKCVKKC EKKCEKKCEK
KCEKKCEKKC EKKCEKKCEK KCEKKCEKKC EKKCEKKCEK KCEKKCNHYD LDEKKYDQHD
LCDQKYDQHD LCDQKYDQHD LCDQKYDQTC NILNNNIYYK DETNLTMRFP LKVEKEHNNV
PNMNNGSNIY KNVNTYNNFD NIKKIENITY EGANKLDMLK KGENINLFIN KINCKSKMEN
ILKEFNINDF FNLDKNGMFL LFQMSLSNCF YIMNNIFFFY HHNNNNMDRS SNYLINIFIE
NILEFYIHLN VTYVHYKNKL YFILQENVEN LKDIYKHIIY KINTCVHYDE IRNFALKMKN
FIIISSDIRS VQNNKMLTLI PWIIFQLFFI KNHMKKIIQC TTYMFLLFFI FSTDFLFDEC
INIYFIHLLM QFENKKYKKF NLAHRNNNND NDNNDHTDRM RMRYYDDNNN NNDHTDRMRM
RYYDDNNNND HTDRMRMRYY DDNNNNDHTD RMRMRYYDHR HNNINISIFN YQLYKKQKEK
FHKFLSTFNY QKDIYDNNFI KIFHLKKKNI FLKKKTILYN LEMFRNELDF NIITYIMKRL
YSFDLSYLLN LFSTDSTYNH MESHNPETYV RSTNTKEDIQ KNLYIPDKTN YSFKNICNVN
YNNNNNNNNN NNNNEHAKNG SPNKDVYCNI TNKINLLNKK KETKISIFKG GHKHVVNKKK
KKKDIPLSNK RMEKKKNKIN NICSINFCRN QLRYILLLYV KRLIMVLEGL KKNEHEKNDG
RIYKDNINNA DDNNDDDNIN DDDNINDDDN INDDDNNNDD DNNNDDNNDD NNINNDNNDD
DNNNNNNIYN NYYHNKKELI LNIMKYILFF SCTKKYTNVC LLLFDYFGYY NVVIQYYKKY
KLNDLYEYIY FKIYSFYKET RLKKRIYGYL FYTTLLKNIT SLNNLFVHYI LNNYFFFHSK
SMYMLKKRKK KKIQKGRIWK REENGEKKKN EKNESEKNER NEKNEKNEKH EKHEKHEKNE
KNGSVNMIKC KDKGDKNDEH NIERFGKKQM KEFMVMSYPE RTIQYKEENI LSFKNDILYN
KDVCNNINKY NNKKYCKNLS LYHVKNYFFH ISLYFIKSLL CSRNNFNDLI KMRIYFLLLY
KIKFVRKIKS YLFKKHFVKY IDLLCKYNKD KVYKCVKSIN CETYISIYEK HHNINVILYI
YEKQGKFFKV IQICLKEIKN NISKLYNILK KFFKNNNNNN KKKKNKKKNI YIKSFFFSTK
VTYDDMFCIN FDHHVDIYNF YKIPLKKKIT KCLFCSCKEK TQQIVKDKNL FIQKMFGDLN
YISKERSFFL ECFVINKRRR GMATCVRSED IPNVMDIKKG HDHMSINKST NEYLNKRKNQ
ENYHNLQNTY CNLHSCYEKG IHWSNRYGKY NNCENIKGHK KRLIKSRWLF IIKEYNNIFL
YIYMLSFILK KNKITNNKIN EYIISYILNQ CINGYINIHE KVINSTLNKK KKKKKLLFFF
NYIFEQIILF VININSYNHT QNVCQKILSQ YKQKFDIKLI KMPIIQVLKN LCDTYMFFND
TNEIAQKNIK ESMKYYSYQK KKGLIINFEQ SNHKHKFNMN LDKKSYVLSL NKQNLNHTIT
KSYFSQPSNI IYIYKCDHSN HFACTNLCYV CDYESAQEI
