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YPF17_PLAF7
ID   YPF17_PLAF7             Reviewed;        4662 AA.
AC   Q8ILR9; A0A144A1P7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   23-FEB-2022, entry version 74.
DE   RecName: Full=Protein PF3D7_1417600;
GN   ORFNames=PF14_0175, PF3D7_1417600;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 3419-3445, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; LN999946; CZT99887.1; -; Genomic_DNA.
DR   RefSeq; XP_001348348.1; XM_001348312.1.
DR   STRING; 5833.PF14_0175; -.
DR   PRIDE; Q8ILR9; -.
DR   EnsemblProtists; CZT99887; CZT99887; PF3D7_1417600.
DR   GeneID; 811756; -.
DR   KEGG; pfa:PF3D7_1417600; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1417600; -.
DR   HOGENOM; CLU_223536_0_0_1; -.
DR   InParanoid; Q8ILR9; -.
DR   OMA; EGECNNE; -.
DR   PhylomeDB; Q8ILR9; -.
DR   Proteomes; UP000001450; Chromosome 14.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR014012; HSA_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   PANTHER; PTHR24365; PTHR24365; 3.
PE   1: Evidence at protein level;
KW   Coiled coil; DNA-binding; Leucine-rich repeat; Membrane; Merozoite;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..4662
FT                   /note="Protein PF3D7_1417600"
FT                   /id="PRO_0000361759"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          466..489
FT                   /note="LRR 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          783..856
FT                   /note="HSA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00549"
FT   REPEAT          1150..1172
FT                   /note="LRR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2063..2086
FT                   /note="LRR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2129..2153
FT                   /note="LRR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2672..2695
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2773..2796
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2864..2888
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2904..2929
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3377..3400
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3438..3461
FT                   /note="LRR 10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3756..3781
FT                   /note="LRR 11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3935..3960
FT                   /note="LRR 12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3965..3985
FT                   /note="LRR 13"
FT                   /evidence="ECO:0000255"
FT   REPEAT          3986..4010
FT                   /note="LRR 14"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4296..4321
FT                   /note="LRR 15"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4333..4357
FT                   /note="LRR 16"
FT                   /evidence="ECO:0000255"
FT   REGION          583..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          942..967
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1505..1540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1705..1761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2228..2261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2956..2975
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4384..4412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          4203..4272
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        588..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..710
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        942..958
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1709..1761
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4662 AA;  548869 MW;  9ED689B3D6FA2628 CRC64;
     MNSNKNFVNK LYRYYRKNDN YNKKRIFIYE NTVYYTPDDC VFCTQLNCTI KKRWDKKKKK
     KLKSAEKEEY FKDYKYFETE NNDNTDEYYK NDEEENEASD LMITYCDRHV SLINILVNMF
     KIYNKKKTYL NVTLNINYVF LQIIYNIILY FVYLYIYYTK YIYYILRTYL FLLLYNSFHI
     IRENCYYPNI FLYNYYRNRI KKNILQQWKM KKKKKKKKRK KKKHSLFLCK KNMRDTKSNH
     FVRNYSYKII KDSYTNHVDD VIIKFLLYMF YEKFINKFNK YINIHHHYHN VYKKIYYYKI
     KEGMLPFLCD HIFKCNYNLF YIFNRYNFQF NAYNILLNCK EKNSEQIFIF FNKKFLIKKD
     YVMNYLIYVI NNIREKINKI KIIYDDTKKC YFIFYKNKCT SCLITHNILN VPIEGIKKKS
     DNIYFEKPKT NIKNEDVNCK YNKIFYKYYI SVINDMLCIS KNNMIIKNID SINKNHKRLI
     KISNYNITNV CMFLLLPEIF CKYYKKGDKK KKKNKNVKKI IFKERRVNIK SYKILLKCEI
     LTHFNFFNVI NCDRYIYQNN LYNNLVGLKK GSYMKTCTND ETYRNDGDVN NKNGYNNNEH
     SNSSNERSNN NGDNNNNNHN NNNHNNNHHN NGSNNHNGNN NSNNDDNDKD DDKKGNDKKN
     EDKDDENKSD DDNDDDKKNG DGLNRSLDTK KRKEKSKNKN KMKPDNTLNE NVKELLFDKE
     GKSYTCTNND LSLVNNTICE SIKKRKSNRG EKRNYNNEKN DKNSLNNVIA ENAYKIIKNG
     RLYKPTEPVN IFRSHNKFML KEMMWMSIDY YEEKRWKKNV SKKFGYLMSN HFEEKKKNDK
     YFISSQISND IKMFWFFMLN EIRPDLVPVD LDHKIKNKNH LKNDFLNSFR KNLQIEEYNL
     EMDDNNQYSF NQHDGINEES SVQNKSEKNS FSINTSIDDN WGLMNKMSHQ NGKNNNHNDY
     NNKCEDNKNN DYNNNKCDDN NNNDYNNNKC DDNKNNDYNN KCEDNKNNDY NNNKCDDNNN
     DDYNNKCDDN NHNDYNNKCD VNKLNNISIE HTNCINSNKY NLLNISTHKE INMIDNNTND
     ISTVCCENNN NNNNNNNNNE RNNHINVMKK KNIIDYENYD QIVMNIEENV NKELLKKHKI
     YKKDYYTVEN VHINHIQYDD NNLYYNDDLY NYYQSKNDDG YLDLSNHLYI YCLLFISISL
     IEINEHINFS RPDNHLPNDV DNALLEDEQN NSNNNNYNNY NNDIFVNYMN AYNNGELFCN
     NTQRDNIKFP QYGTFKKIKN EFEDFRELKK KKKTDMLKNN KDGLLSNVDN INLDIIRKGN
     TEFKENKIVL NNENNVCYPN AKRNSIMDKD IYENEKDINN CENNILRGKQ ENIKNYEENK
     MIETYYDEML LKKKSINQLR LISEEMLLSK RENDNGNDYK NKNFIDHYDE ENYNGYDKLN
     KYVNKRILSI DNNNNNNNIE NKLDSFVVHK NMNNSNIYNI LSVPSLNNTD VKDLVVIPYS
     CDNNNNNNNS NNNNSNSNNN SNSNIKTKES VSTTNHNNSS NNIIYENIKN DYINEIKEKN
     VNVYLHNMEL YGGIPYPFEY KYIDDFYDDI NLPLMNLAEY DKYTFFLYLF YMKNSSYILK
     KQMKKDKRKR KKEFTDVLLT KKRTPKRKIN KLENEKKIEQ IEDAEKVLSS EKVVDGENIL
     KVINDQNNLS NEVNIIKDVT ISGTKINSKN NDKSDDKNDD KNDKKNDGKN DKNDEKDDNK
     TGEKGDNKIG EKDDNKINEK DDNKINDKEI VGTVLRTSTK NKTKNKLKNK DGYVIKKEHL
     GDLEERQQKK IKKKEMETIK KWKEKKDEWE LEETNFLLIL TKTYMNYINM DEIIKREYGI
     SLNSCTALGD IKNKNNMNNM NNMNNMNNMN NMNNMNNMNN IDETDNGNNI NIENNVYNSN
     NGNINNVVEI KNANNSKTKE HEEINNDNSN VENKNVTNDF IKKYKGHEYI MSFNKFENNI
     NNKLKNYTDF INWNIISVAL VSYNKISHIY EKKRGPNECK EKFLSLIKDD IYKITKLQNL
     YHDYYLNTIK NNNSMKRKKK KCITKVKFLP LFSSNNVNKL IGMFNKYMNE KLKKYELKKM
     DMNNNNKIET LKVKNIIIKN EKIEEKKHDE EINILNKNDD KINEYKDELN VKDEDIHLIK
     KVKKKSSIIK KKKKGFFHNL FSTFSGKKSR ESSEEDTDCG RDSFFSCSDV EISATKLDDS
     CISFSNNKNK SNKKKRAKKN IKLGEEENES ECNNEGECNN EGECNNEGEC NNEGECNNEG
     ECNNEGEGNN ESEIASTKKE LLDINNKIND ENDNHNFNKK RSSISYYFDD YFDEHFEDYL
     DDYFEDEWDD YVDENFVDNS DEFFEEDVNE FKKINNIDEN TTNNNSTDII KKNEKNNIEH
     IKELNNTYVD ENSHIEKKEP TICVNIKNST NENNNILINN DTFKSKDEKK DTYNKEVCVN
     SISQLIIYNK CKDDEYKYDF NYILKNRDKI KKWLNCICKN KKNIKEFMNI INNDYFVKNK
     YFHRLIESVV NNVSKEQSSF TYSNNIIINS LNKEPDYELT YRENSNDRNI NNPLDNEFIK
     MIRKIMEYDK KRKLKSIQKL KNISNNYSYN TINEFYISKP NESYNTVNEF VQKILNYVPY
     VDDKKKIIIK KIRKRFQCKN LITQILLADY ILDKLKNFPI NESIESSKNN NKTIDMLLSE
     TRLKAYSKYI NEHFNDNYDP VKIETSFLKM FSSENDELYK KNILNNNNNK EVTHINIKSE
     EVALNKSIQE TTNTVLKDTI IESNEISCIV DKTVDIHNEQ NDKKHDTSPA DINNKDYIGY
     MHVNKKELVS MQNSSNPSDI IQQCVNKVEV YNKDVCQTNG YMNINDDNKM NNFVNNNITH
     INNNVNNNNN IVNHLNNNNN NNNANNINNL NVNHLNNNIS QINNNYNNSN MSSIYIASDQ
     NEHFNKMTVM EKQDPMNNTK QRSHSSYHTS FPMQNNNTPL YNKLEGDQIK LSKYNSLESN
     KNNIDIISTN NNATKTKDHV IKANNKGSTR GKRQTLSLVK PHKESEHVQD SSVINQPVKN
     VSSKGEEIIL GNNRQKSQPI KNVDITNKMT KYKTSVSSSI LSSDKLKNNN ILNTVQNESA
     YLSSKFNSNV QTLNNNVNNN VNINVNNMNS NISNNMNSNI NNNMNSNMCN NMNSNMSNNM
     NSNMHVMDQG SFFTSNMVNR EVNNLLNEEQ RINTNVVSSH YNSVVSSTQF INDRGNYTNR
     IQKILSNNKY SLTPMKNNIT QENMNNCIVN HQTPNKNIQE YYIPNASPNK LNKSISNVDI
     MKSNTSSILY PQAHNSVSSN FNNVSETLQN VNVLHASKKY HMNNSNDICT NINNNNNNNN
     NNNNNNNNNV HHNSMNQNNM NTINMNNINM NNINMNNITM NNINMNNINM NNINMNNTNN
     NVNNINMNNI NSNVNNINNS MNNINISNNI NYNISNNYNN SVSMYNIPNK EDDKFISPLH
     SSMQNNKYMP INRNNSSMSY NKTPICDSVE LPIKQMSGNI SNNCNASMQL EVSSNSSSKK
     LQHTIGSNTI NTDKKSLLMY IENRARTGSS SINKINDDMF SIKSSTPSNY PPSYTTHQQF
     ISESENKSNL YHDQMLNQDV IMDNKNVQNF TYAPCSNSLN NNLKNTNTMN NETRSNIISN
     YKQVKYSNIS VNNTPNNVIM QTQNMTVQNN AKMSLNGSTT HPIVNRTNME NIDLIKLAND
     PLNIHRNGIH MGNIKNDNIE EKKNVSSNIR SIADNSQRLQ NIHLGNQQND IQHMNLDNIN
     NNNNNNNLKM KKKSKNNINI NNNPNNNLNN NGQIDNAYLN VSPTISNSLQ QTNMYQSDMK
     NSIIYNSSIQ EKDPNNRNYN TQGNNVQTMN QSNGNVYNVN VPNRKQSNLN QYVNPMNFLI
     QVLNKCNSNT NGQVKASASN ANVNYANVNS TSLNQPNINN VGMNQPNINN VGMNQPNINN
     VGMNQPNINN VGMNQPNINN VSMNQPNINN VNMNQPNINN VSMNQPNINN FSMNQSNTNN
     FNMNKPSTSS FSMNQPSTNN FSMNKSSTNN FSINQTSANN FSMHQPSTNN FSMNKPSTNN
     FSTNKPSTNN FSMNQPNINN ISMNQPNTNN VHMNNLNMNQ SGMNHTNMTS PIFNQSNSSK
     QSVNENAFVP PAYHTSNIIQ KNATSVYNDN FNNPNVVNVG LKNTMTKNII QRVPQKKGYS
     THDMNQQERL QQERLQQERL QQERLQQERL QQERLQQERL QQERLQQERL QQERLQQERL
     QQERLQQKWE QQKIQQELYQ KSHNDKESET NNSSSYQELN NHTLQENTIA KDSMRQHIFL
     KTRQQENIPK ELQKMHSHQL QTEKMKTQQL SAHSLQQQMY PQQMTSQVHS SFHAQKIKQQ
     LQQQMNHQQI NKHQMNQQQM NKQQMNQQQI NQQQMNQQQI NQQQINQQQI NQQQINQQQI
     NQQQINQQQI NQQQINQQQI NQQQINQQSM SKYPYQAQEI KKHMDQLQQN VSIVTQQKMQ
     PIYSVKQNMP FNEENEMKRN TRKITLPMTH QIPNVPNIQQ QINNKMDERM STENINENNL
     YNMMNRKLST SINKFNNHDQ YYPYDSYQQQ QLQGNNINVM DIRNVDKNEN NIFLLKNNQS
     RDIQNNCTNI MMNNNIPSSY ITPGQAYKLN SNQNINHTQQ KK
 
 
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