YPF17_PLAF7
ID YPF17_PLAF7 Reviewed; 4662 AA.
AC Q8ILR9; A0A144A1P7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 23-FEB-2022, entry version 74.
DE RecName: Full=Protein PF3D7_1417600;
GN ORFNames=PF14_0175, PF3D7_1417600;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000305}
RP SYNTHESIS OF 3419-3445, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999946; CZT99887.1; -; Genomic_DNA.
DR RefSeq; XP_001348348.1; XM_001348312.1.
DR STRING; 5833.PF14_0175; -.
DR PRIDE; Q8ILR9; -.
DR EnsemblProtists; CZT99887; CZT99887; PF3D7_1417600.
DR GeneID; 811756; -.
DR KEGG; pfa:PF3D7_1417600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1417600; -.
DR HOGENOM; CLU_223536_0_0_1; -.
DR InParanoid; Q8ILR9; -.
DR OMA; EGECNNE; -.
DR PhylomeDB; Q8ILR9; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24365; PTHR24365; 3.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Leucine-rich repeat; Membrane; Merozoite;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..4662
FT /note="Protein PF3D7_1417600"
FT /id="PRO_0000361759"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 466..489
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT DOMAIN 783..856
FT /note="HSA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00549"
FT REPEAT 1150..1172
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 2063..2086
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 2129..2153
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 2672..2695
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 2773..2796
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 2864..2888
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 2904..2929
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 3377..3400
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 3438..3461
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 3756..3781
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 3935..3960
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 3965..3985
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 3986..4010
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 4296..4321
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 4333..4357
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REGION 583..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2228..2261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2956..2975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4384..4412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4203..4272
FT /evidence="ECO:0000255"
FT COMPBIAS 588..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4662 AA; 548869 MW; 9ED689B3D6FA2628 CRC64;
MNSNKNFVNK LYRYYRKNDN YNKKRIFIYE NTVYYTPDDC VFCTQLNCTI KKRWDKKKKK
KLKSAEKEEY FKDYKYFETE NNDNTDEYYK NDEEENEASD LMITYCDRHV SLINILVNMF
KIYNKKKTYL NVTLNINYVF LQIIYNIILY FVYLYIYYTK YIYYILRTYL FLLLYNSFHI
IRENCYYPNI FLYNYYRNRI KKNILQQWKM KKKKKKKKRK KKKHSLFLCK KNMRDTKSNH
FVRNYSYKII KDSYTNHVDD VIIKFLLYMF YEKFINKFNK YINIHHHYHN VYKKIYYYKI
KEGMLPFLCD HIFKCNYNLF YIFNRYNFQF NAYNILLNCK EKNSEQIFIF FNKKFLIKKD
YVMNYLIYVI NNIREKINKI KIIYDDTKKC YFIFYKNKCT SCLITHNILN VPIEGIKKKS
DNIYFEKPKT NIKNEDVNCK YNKIFYKYYI SVINDMLCIS KNNMIIKNID SINKNHKRLI
KISNYNITNV CMFLLLPEIF CKYYKKGDKK KKKNKNVKKI IFKERRVNIK SYKILLKCEI
LTHFNFFNVI NCDRYIYQNN LYNNLVGLKK GSYMKTCTND ETYRNDGDVN NKNGYNNNEH
SNSSNERSNN NGDNNNNNHN NNNHNNNHHN NGSNNHNGNN NSNNDDNDKD DDKKGNDKKN
EDKDDENKSD DDNDDDKKNG DGLNRSLDTK KRKEKSKNKN KMKPDNTLNE NVKELLFDKE
GKSYTCTNND LSLVNNTICE SIKKRKSNRG EKRNYNNEKN DKNSLNNVIA ENAYKIIKNG
RLYKPTEPVN IFRSHNKFML KEMMWMSIDY YEEKRWKKNV SKKFGYLMSN HFEEKKKNDK
YFISSQISND IKMFWFFMLN EIRPDLVPVD LDHKIKNKNH LKNDFLNSFR KNLQIEEYNL
EMDDNNQYSF NQHDGINEES SVQNKSEKNS FSINTSIDDN WGLMNKMSHQ NGKNNNHNDY
NNKCEDNKNN DYNNNKCDDN NNNDYNNNKC DDNKNNDYNN KCEDNKNNDY NNNKCDDNNN
DDYNNKCDDN NHNDYNNKCD VNKLNNISIE HTNCINSNKY NLLNISTHKE INMIDNNTND
ISTVCCENNN NNNNNNNNNE RNNHINVMKK KNIIDYENYD QIVMNIEENV NKELLKKHKI
YKKDYYTVEN VHINHIQYDD NNLYYNDDLY NYYQSKNDDG YLDLSNHLYI YCLLFISISL
IEINEHINFS RPDNHLPNDV DNALLEDEQN NSNNNNYNNY NNDIFVNYMN AYNNGELFCN
NTQRDNIKFP QYGTFKKIKN EFEDFRELKK KKKTDMLKNN KDGLLSNVDN INLDIIRKGN
TEFKENKIVL NNENNVCYPN AKRNSIMDKD IYENEKDINN CENNILRGKQ ENIKNYEENK
MIETYYDEML LKKKSINQLR LISEEMLLSK RENDNGNDYK NKNFIDHYDE ENYNGYDKLN
KYVNKRILSI DNNNNNNNIE NKLDSFVVHK NMNNSNIYNI LSVPSLNNTD VKDLVVIPYS
CDNNNNNNNS NNNNSNSNNN SNSNIKTKES VSTTNHNNSS NNIIYENIKN DYINEIKEKN
VNVYLHNMEL YGGIPYPFEY KYIDDFYDDI NLPLMNLAEY DKYTFFLYLF YMKNSSYILK
KQMKKDKRKR KKEFTDVLLT KKRTPKRKIN KLENEKKIEQ IEDAEKVLSS EKVVDGENIL
KVINDQNNLS NEVNIIKDVT ISGTKINSKN NDKSDDKNDD KNDKKNDGKN DKNDEKDDNK
TGEKGDNKIG EKDDNKINEK DDNKINDKEI VGTVLRTSTK NKTKNKLKNK DGYVIKKEHL
GDLEERQQKK IKKKEMETIK KWKEKKDEWE LEETNFLLIL TKTYMNYINM DEIIKREYGI
SLNSCTALGD IKNKNNMNNM NNMNNMNNMN NMNNMNNMNN IDETDNGNNI NIENNVYNSN
NGNINNVVEI KNANNSKTKE HEEINNDNSN VENKNVTNDF IKKYKGHEYI MSFNKFENNI
NNKLKNYTDF INWNIISVAL VSYNKISHIY EKKRGPNECK EKFLSLIKDD IYKITKLQNL
YHDYYLNTIK NNNSMKRKKK KCITKVKFLP LFSSNNVNKL IGMFNKYMNE KLKKYELKKM
DMNNNNKIET LKVKNIIIKN EKIEEKKHDE EINILNKNDD KINEYKDELN VKDEDIHLIK
KVKKKSSIIK KKKKGFFHNL FSTFSGKKSR ESSEEDTDCG RDSFFSCSDV EISATKLDDS
CISFSNNKNK SNKKKRAKKN IKLGEEENES ECNNEGECNN EGECNNEGEC NNEGECNNEG
ECNNEGEGNN ESEIASTKKE LLDINNKIND ENDNHNFNKK RSSISYYFDD YFDEHFEDYL
DDYFEDEWDD YVDENFVDNS DEFFEEDVNE FKKINNIDEN TTNNNSTDII KKNEKNNIEH
IKELNNTYVD ENSHIEKKEP TICVNIKNST NENNNILINN DTFKSKDEKK DTYNKEVCVN
SISQLIIYNK CKDDEYKYDF NYILKNRDKI KKWLNCICKN KKNIKEFMNI INNDYFVKNK
YFHRLIESVV NNVSKEQSSF TYSNNIIINS LNKEPDYELT YRENSNDRNI NNPLDNEFIK
MIRKIMEYDK KRKLKSIQKL KNISNNYSYN TINEFYISKP NESYNTVNEF VQKILNYVPY
VDDKKKIIIK KIRKRFQCKN LITQILLADY ILDKLKNFPI NESIESSKNN NKTIDMLLSE
TRLKAYSKYI NEHFNDNYDP VKIETSFLKM FSSENDELYK KNILNNNNNK EVTHINIKSE
EVALNKSIQE TTNTVLKDTI IESNEISCIV DKTVDIHNEQ NDKKHDTSPA DINNKDYIGY
MHVNKKELVS MQNSSNPSDI IQQCVNKVEV YNKDVCQTNG YMNINDDNKM NNFVNNNITH
INNNVNNNNN IVNHLNNNNN NNNANNINNL NVNHLNNNIS QINNNYNNSN MSSIYIASDQ
NEHFNKMTVM EKQDPMNNTK QRSHSSYHTS FPMQNNNTPL YNKLEGDQIK LSKYNSLESN
KNNIDIISTN NNATKTKDHV IKANNKGSTR GKRQTLSLVK PHKESEHVQD SSVINQPVKN
VSSKGEEIIL GNNRQKSQPI KNVDITNKMT KYKTSVSSSI LSSDKLKNNN ILNTVQNESA
YLSSKFNSNV QTLNNNVNNN VNINVNNMNS NISNNMNSNI NNNMNSNMCN NMNSNMSNNM
NSNMHVMDQG SFFTSNMVNR EVNNLLNEEQ RINTNVVSSH YNSVVSSTQF INDRGNYTNR
IQKILSNNKY SLTPMKNNIT QENMNNCIVN HQTPNKNIQE YYIPNASPNK LNKSISNVDI
MKSNTSSILY PQAHNSVSSN FNNVSETLQN VNVLHASKKY HMNNSNDICT NINNNNNNNN
NNNNNNNNNV HHNSMNQNNM NTINMNNINM NNINMNNITM NNINMNNINM NNINMNNTNN
NVNNINMNNI NSNVNNINNS MNNINISNNI NYNISNNYNN SVSMYNIPNK EDDKFISPLH
SSMQNNKYMP INRNNSSMSY NKTPICDSVE LPIKQMSGNI SNNCNASMQL EVSSNSSSKK
LQHTIGSNTI NTDKKSLLMY IENRARTGSS SINKINDDMF SIKSSTPSNY PPSYTTHQQF
ISESENKSNL YHDQMLNQDV IMDNKNVQNF TYAPCSNSLN NNLKNTNTMN NETRSNIISN
YKQVKYSNIS VNNTPNNVIM QTQNMTVQNN AKMSLNGSTT HPIVNRTNME NIDLIKLAND
PLNIHRNGIH MGNIKNDNIE EKKNVSSNIR SIADNSQRLQ NIHLGNQQND IQHMNLDNIN
NNNNNNNLKM KKKSKNNINI NNNPNNNLNN NGQIDNAYLN VSPTISNSLQ QTNMYQSDMK
NSIIYNSSIQ EKDPNNRNYN TQGNNVQTMN QSNGNVYNVN VPNRKQSNLN QYVNPMNFLI
QVLNKCNSNT NGQVKASASN ANVNYANVNS TSLNQPNINN VGMNQPNINN VGMNQPNINN
VGMNQPNINN VGMNQPNINN VSMNQPNINN VNMNQPNINN VSMNQPNINN FSMNQSNTNN
FNMNKPSTSS FSMNQPSTNN FSMNKSSTNN FSINQTSANN FSMHQPSTNN FSMNKPSTNN
FSTNKPSTNN FSMNQPNINN ISMNQPNTNN VHMNNLNMNQ SGMNHTNMTS PIFNQSNSSK
QSVNENAFVP PAYHTSNIIQ KNATSVYNDN FNNPNVVNVG LKNTMTKNII QRVPQKKGYS
THDMNQQERL QQERLQQERL QQERLQQERL QQERLQQERL QQERLQQERL QQERLQQERL
QQERLQQKWE QQKIQQELYQ KSHNDKESET NNSSSYQELN NHTLQENTIA KDSMRQHIFL
KTRQQENIPK ELQKMHSHQL QTEKMKTQQL SAHSLQQQMY PQQMTSQVHS SFHAQKIKQQ
LQQQMNHQQI NKHQMNQQQM NKQQMNQQQI NQQQMNQQQI NQQQINQQQI NQQQINQQQI
NQQQINQQQI NQQQINQQQI NQQQINQQSM SKYPYQAQEI KKHMDQLQQN VSIVTQQKMQ
PIYSVKQNMP FNEENEMKRN TRKITLPMTH QIPNVPNIQQ QINNKMDERM STENINENNL
YNMMNRKLST SINKFNNHDQ YYPYDSYQQQ QLQGNNINVM DIRNVDKNEN NIFLLKNNQS
RDIQNNCTNI MMNNNIPSSY ITPGQAYKLN SNQNINHTQQ KK
