ID   YPFJ1_PLAF7             Reviewed;         492 AA.
AC   Q8IM77; A0A144A181;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized J domain-containing protein PF3D7_1401100;
GN   ORFNames=PF14_0013, PF3D7_1401100;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 389-421, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; LN999946; CZT99717.1; -; Genomic_DNA.
DR   RefSeq; XP_001348186.2; XM_001348150.2.
DR   AlphaFoldDB; Q8IM77; -.
DR   BioGRID; 1206968; 2.
DR   IntAct; Q8IM77; 1.
DR   STRING; 5833.PF14_0013; -.
DR   EnsemblProtists; CZT99717; CZT99717; PF3D7_1401100.
DR   GeneID; 811599; -.
DR   KEGG; pfa:PF3D7_1401100; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1401100; -.
DR   HOGENOM; CLU_583291_0_0_1; -.
DR   InParanoid; Q8IM77; -.
DR   OMA; DMKIESF; -.
DR   PhylomeDB; Q8IM77; -.
DR   Proteomes; UP000001450; Chromosome 14.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR026894; DnaJ_X.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF14308; DnaJ-X; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Merozoite; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..492
FT                   /note="Uncharacterized J domain-containing protein
FT                   PF3D7_1401100"
FT                   /id="PRO_0000371257"
FT   TRANSMEM        30..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          144..210
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   492 AA;  57094 MW;  821EF75BCCE28CEB CRC64;
     MSNRQSIDDM NLSVKNKKSK SIFSCRPVKY VCLSVAVAAV GYANYMNNGD RNSLSCVDLN
     NVYSRNLSES QENHNSSFTR TNLVENENEE DDIFGVHRDE SFAETVLNGQ DIISYLEHQN
     TKIHEDNIHD DISHTLLNEG DVQNYYDVLN VNEHSDLNEL KRNFHNLSLQ HYPKITSDNS
     FELNDEFNQL SEAYQVLSYQ IRKNIYDNEG VYGTKKMAIV NPLIYFNGIF TTQLMHEYIG
     TTEVAQFVQL FLERNIAPEN IVSFLEESVS DMMKGQDYRE LQLTELLKQK LDLYINDDEK
     WQNIIKSEIN VLTKSPFSKF ILEAVGWTYE NVGNIYMEQT DNFDNVYHGI YVNLADERIN
     RNYAILDENV NDFVSLLKKF YPFTETVNPY LRRAKHNLNN LQGGINNLYS SVNVVYDNLF
     NENINISSNE HYHLLQELLK IILNINLCDI EETIRECAYN VLKDKTVDAS VHSKRAHRMN
     ILGSLMLESS NE