YPHA_ECOLI
ID YPHA_ECOLI Reviewed; 140 AA.
AC P0AD47; O08101; P77751;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Inner membrane protein YphA;
GN Name=yphA; OrderedLocusNames=b2543, JW2527;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / MC1061 / ATCC 53338 / DSM 7140;
RA Diaz E., Ferrandez A., Garcia J.L.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the DoxX family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA16446.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA71953.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y11070; CAA71953.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC75596.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16446.1; ALT_INIT; Genomic_DNA.
DR PIR; F65031; F65031.
DR RefSeq; NP_417038.4; NC_000913.3.
DR RefSeq; WP_001094726.1; NZ_STEB01000011.1.
DR AlphaFoldDB; P0AD47; -.
DR BioGRID; 4260605; 11.
DR STRING; 511145.b2543; -.
DR PaxDb; P0AD47; -.
DR PRIDE; P0AD47; -.
DR EnsemblBacteria; AAC75596; AAC75596; b2543.
DR EnsemblBacteria; BAA16446; BAA16446; BAA16446.
DR GeneID; 58460706; -.
DR GeneID; 947365; -.
DR KEGG; ecj:JW2527; -.
DR KEGG; eco:b2543; -.
DR PATRIC; fig|1411691.4.peg.4191; -.
DR EchoBASE; EB3235; -.
DR eggNOG; COG2259; Bacteria.
DR HOGENOM; CLU_058421_8_1_6; -.
DR InParanoid; P0AD47; -.
DR OMA; HDFWNQT; -.
DR PhylomeDB; P0AD47; -.
DR BioCyc; EcoCyc:G7337-MON; -.
DR PRO; PR:P0AD47; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR032808; DoxX.
DR Pfam; PF07681; DoxX; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..140
FT /note="Inner membrane protein YphA"
FT /id="PRO_0000169257"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..56
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..116
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 140 AA; 15211 MW; 99C536AA10AAD2C9 CRC64;
MNTLRYFDFG AARPVLLLIA RIAVVLIFII FGFPKMMGFD GTVQYMASLG APMPMLAAII
AVVMEVPAAI LIVLGFFTRP LAVLFIFYTL GTAVIGHHYW DMTGDAVGPN MINFWKNVSI
AGAFLLLAIT GPGAISLDRR
