ID   YPHA_SHIFL              Reviewed;         140 AA.
AC   P0AD48; O08101; P77751;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Inner membrane protein YphA;
GN   Name=yphA; OrderedLocusNames=SF2590, S2762;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DoxX family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN44088.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP17913.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN44088.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP17913.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_708381.1; NC_004337.2.
DR   RefSeq; WP_001094726.1; NZ_WPGW01000021.1.
DR   AlphaFoldDB; P0AD48; -.
DR   STRING; 198214.SF2590; -.
DR   EnsemblBacteria; AAN44088; AAN44088; SF2590.
DR   EnsemblBacteria; AAP17913; AAP17913; S2762.
DR   GeneID; 1026951; -.
DR   GeneID; 58460706; -.
DR   KEGG; sfl:SF2590; -.
DR   KEGG; sfx:S2762; -.
DR   PATRIC; fig|198214.7.peg.3091; -.
DR   HOGENOM; CLU_058421_8_1_6; -.
DR   OrthoDB; 2084223at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032808; DoxX.
DR   Pfam; PF07681; DoxX; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..140
FT                   /note="Inner membrane protein YphA"
FT                   /id="PRO_0000169258"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..56
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..116
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   140 AA;  15211 MW;  99C536AA10AAD2C9 CRC64;
     MNTLRYFDFG AARPVLLLIA RIAVVLIFII FGFPKMMGFD GTVQYMASLG APMPMLAAII
     AVVMEVPAAI LIVLGFFTRP LAVLFIFYTL GTAVIGHHYW DMTGDAVGPN MINFWKNVSI
     AGAFLLLAIT GPGAISLDRR