ID   CBPH_APLCA              Reviewed;          86 AA.
AC   Q8T112;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Cerebrin prohormone;
DE   Contains:
DE     RecName: Full=Cerebrin;
DE   Flags: Precursor;
GN   Name=CBPH;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-83, FUNCTION, MASS
RP   SPECTROMETRY, TISSUE SPECIFICITY, AND AMIDATION AT ILE-83.
RX   PubMed=11413240; DOI=10.1046/j.1471-4159.2001.00360.x;
RA   Li L., Floyd P.D., Rubakhin S.S., Romanova E.V., Jing J., Alexeeva V.Y.,
RA   Dembrow N.C., Weiss K.R., Vilim F.S., Sweedler J.V.;
RT   "Cerebrin prohormone processing, distribution and action in Aplysia
RT   californica.";
RL   J. Neurochem. 77:1569-1580(2001).
CC   -!- FUNCTION: May function as a hormone and may play a neuromodulatory
CC       role. {ECO:0000269|PubMed:11413240}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed only in cerebral ganglion.
CC       {ECO:0000269|PubMed:11413240}.
CC   -!- MASS SPECTROMETRY: [Cerebrin prohormone]: Mass=4215; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11413240};
CC   -!- MASS SPECTROMETRY: [Cerebrin]: Mass=1803; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11413240};
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DR   EMBL; AF362572; AAM00268.1; -; mRNA.
DR   RefSeq; NP_001191498.1; NM_001204569.1.
DR   RefSeq; XP_012944002.1; XM_013088548.1.
DR   RefSeq; XP_012944003.1; XM_013088549.1.
DR   AlphaFoldDB; Q8T112; -.
DR   GeneID; 100533259; -.
DR   CTD; 100533259; -.
DR   OrthoDB; 1653324at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT   CHAIN           28..86
FT                   /note="Cerebrin prohormone"
FT                   /id="PRO_0000255265"
FT   PROPEP          28..64
FT                   /id="PRO_0000255266"
FT   PEPTIDE         67..83
FT                   /note="Cerebrin"
FT                   /id="PRO_0000255267"
FT   MOD_RES         83
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:11413240"
SQ   SEQUENCE   86 AA;  9575 MW;  0B8B7B4656FE4170 CRC64;
     MFGYRSLLVL LVTLSLCLLL QSSHCSAVRT YGNDLDARAR REIISLAARL IKLSMYGPED
     DSFVKRNGGT ADALYNLPDL EKIGKR