YPHC_ECOLI
ID YPHC_ECOLI Reviewed; 353 AA.
AC P77360;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC;
DE EC=1.-.-.-;
GN Name=yphC; OrderedLocusNames=b2545, JW5842;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000305}.
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DR EMBL; U00096; AAC75598.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16447.2; -; Genomic_DNA.
DR PIR; H65031; H65031.
DR RefSeq; NP_417040.2; NC_000913.3.
DR RefSeq; WP_001393448.1; NZ_CP047127.1.
DR AlphaFoldDB; P77360; -.
DR SMR; P77360; -.
DR BioGRID; 4261318; 8.
DR STRING; 511145.b2545; -.
DR PaxDb; P77360; -.
DR PRIDE; P77360; -.
DR EnsemblBacteria; AAC75598; AAC75598; b2545.
DR EnsemblBacteria; BAA16447; BAA16447; BAA16447.
DR GeneID; 947019; -.
DR KEGG; ecj:JW5842; -.
DR KEGG; eco:b2545; -.
DR PATRIC; fig|1411691.4.peg.4189; -.
DR EchoBASE; EB3237; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_2_6; -.
DR InParanoid; P77360; -.
DR OMA; FCAVKKE; -.
DR PhylomeDB; P77360; -.
DR BioCyc; EcoCyc:YPHC-MON; -.
DR PRO; PR:P77360; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; SSF50129; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding; Oxidoreductase; Reference proteome; Zinc.
FT CHAIN 1..353
FT /note="Uncharacterized zinc-type alcohol dehydrogenase-like
FT protein YphC"
FT /id="PRO_0000160899"
FT BINDING 40
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 70
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 100
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 106
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 114
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 353 AA; 38051 MW; 71973759FC7334DD CRC64;
MKTMLAAYLP GNSTVDLREV AVPTPGINQV LIKMKSSGIC GSDVHYIYHQ HRATAAAPDK
PLYQGFINGH EPCGQIVAMG QGCRHFKEGD RVLVYHISGC GFCPNCRRGF PISCTGEGKA
AYGWQRDGGH AEYLLAEEKD LILLPDALSY EDGAFISCGV GTAYEGILRG EVSGSDNVLV
VGLGPVGMMA MMLAKGRGAK RIIGVDMLPE RLAMAKQLGV MDHGYLATTE GLPQIIAELT
HGGADVALDC SGNAAGRLLA LQSTADWGRV VYIGETGKVE FEVSADLMHH QRRIIGSWVT
SLFHMEKCAH DLTDWKLWPR NAITHRFSLE QAGDAYALMA SGKCGKVVIN FPD
