ID   YPHE_ECOLI              Reviewed;         503 AA.
AC   P77509;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Uncharacterized ABC transporter ATP-binding protein YphE;
GN   Name=yphE; OrderedLocusNames=b2547, JW2531;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Probably part of a binding-protein-dependent transport system
CC       YphDEF. Probably responsible for energy coupling to the transport
CC       system.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; U00096; AAC75600.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16449.1; -; Genomic_DNA.
DR   PIR; B65032; B65032.
DR   RefSeq; NP_417042.1; NC_000913.3.
DR   RefSeq; WP_000493470.1; NZ_LN832404.1.
DR   AlphaFoldDB; P77509; -.
DR   SMR; P77509; -.
DR   BioGRID; 4261315; 141.
DR   ComplexPortal; CPX-4468; YphDEF ABC transporter complex.
DR   DIP; DIP-12830N; -.
DR   IntAct; P77509; 7.
DR   STRING; 511145.b2547; -.
DR   TCDB; 3.A.1.2.27; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P77509; -.
DR   PRIDE; P77509; -.
DR   EnsemblBacteria; AAC75600; AAC75600; b2547.
DR   EnsemblBacteria; BAA16449; BAA16449; BAA16449.
DR   GeneID; 948990; -.
DR   KEGG; ecj:JW2531; -.
DR   KEGG; eco:b2547; -.
DR   PATRIC; fig|1411691.4.peg.4187; -.
DR   EchoBASE; EB3239; -.
DR   eggNOG; COG1129; Bacteria.
DR   HOGENOM; CLU_000604_92_3_6; -.
DR   InParanoid; P77509; -.
DR   OMA; KMIYGLV; -.
DR   PhylomeDB; P77509; -.
DR   BioCyc; EcoCyc:YPHE-MON; -.
DR   PRO; PR:P77509; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IC:ComplexPortal.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Repeat; Transport.
FT   CHAIN           1..503
FT                   /note="Uncharacterized ABC transporter ATP-binding protein
FT                   YphE"
FT                   /id="PRO_0000093197"
FT   DOMAIN          8..249
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          261..499
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         43..50
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   503 AA;  55016 MW;  0D964916CE97A761 CRC64;
     MFTATEAVPV AKVVAGNKRY PGVVALDNVN FTLNKGEVRA LLGKNGAGKS TLIRMLTGSE
     RPDSGDIWIG ETRLEGDEAT LTRRAAELGV RAVYQELSLV EGLTVAENLC LGQWPRRNGM
     IDYLQMAQDA QRCLQALGVD VSPEQLVSTL SPAQKQLVEI ARVMKGEPRV VILDEPTSSL
     ASAEVELVIS AVKKMSALGV AVIYVSHRME EIRRIASCAT VMRDGQVAGD VMLENTSTHH
     IVSLMLGRDH VDIAPVAPQE IVDQAVLEVR ALRHKPKLED ISFTLRRGEV LGIAGLLGAG
     RSELLKAIVG LEEYEQGEIV INGEKITRPD YGDMLKRGIG YTPENRKEAG IIPWLGVDEN
     TVLTNRQKIS ANGVLQWSTI RRLTEEVMQR MTVKAASSET PIGTLSGGNQ QKVVIGRWVY
     AASQILLLDE PTRGVDIEAK QQIYRIVREL AAEGKSVVFI SSEVEELPLV CDRILLLQHG
     TFSQEFHAPV NVDELMSAIL SVH