CBPK_DICDI
ID CBPK_DICDI Reviewed; 192 AA.
AC Q86IV7; Q556C1; Q6DN50;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Calcium-binding protein K;
GN Name=cbpK; ORFNames=DDB_G0274359;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15606490; DOI=10.1111/j.1440-169x.2004.00761.x;
RA Coukell B., Cameron A., Perusini S., Shim K.;
RT "Disruption of the NCS-1/frequenin-related ncsA gene in Dictyostelium
RT discoideum accelerates development.";
RL Dev. Growth Differ. 46:449-458(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the recoverin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL70072.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY655132; AAT72748.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL70072.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_643889.2; XM_638797.3.
DR AlphaFoldDB; Q86IV7; -.
DR SMR; Q86IV7; -.
DR STRING; 44689.DDB0237507; -.
DR PaxDb; Q86IV7; -.
DR GeneID; 8619315; -.
DR KEGG; ddi:DDB_G0274359; -.
DR dictyBase; DDB_G0274359; cbpK.
DR InParanoid; Q86IV7; -.
DR PhylomeDB; Q86IV7; -.
DR PRO; PR:Q86IV7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005509; F:calcium ion binding; ISS:dictyBase.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; PTHR23055; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..192
FT /note="Calcium-binding protein K"
FT /id="PRO_0000323764"
FT DOMAIN 60..95
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 96..131
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 73
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 75
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 84
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 109
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 111
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 113
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 115
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 120
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT CONFLICT 23
FT /note="E -> G (in Ref. 1; AAT72748)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="A -> T (in Ref. 1; AAT72748)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="F -> I (in Ref. 3; EAL70072)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="S -> F (in Ref. 3; EAL70072)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="S -> F (in Ref. 3; EAL70072)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="Q -> P (in Ref. 3; EAL70072)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 21973 MW; AAD6B5450076EB34 CRC64;
MGNSKLSKEE KEEIIKKTKY TPEDIEQLIK DFKVAAASDK KSGFSQEEFI KFFKVRFSNW
DEASMVRMFT LFDSDGNGVI DVKEFITALY LMAKAPTLDK LGFFFDLFDS DKSGYLEREE
VDKLVNIVVC CGKGLGYSIN DAIDYAVSIT SCRHIADYQK GMSREEFIKS ASQSENFVKV
ICFYESPCMQ LY
