YPL1_DROME
ID YPL1_DROME Reviewed; 114 AA.
AC Q9W2X7; A8JUP6;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein yippee-like {ECO:0000312|FlyBase:FBgn0030183};
DE AltName: Full=Protein yippee-like 3 {ECO:0000303|PubMed:32461240};
GN Name=Ypel {ECO:0000312|FlyBase:FBgn0030183};
GN Synonyms=Ypel3 {ECO:0000303|PubMed:32461240};
GN ORFNames=CG15309 {ECO:0000312|FlyBase:FBgn0030183};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=32461240; DOI=10.1242/dmm.042390;
RA Kim J.H., Singh M., Pan G., Lopez A., Zito N., Bosse B., Ye B.;
RT "Frameshift mutations of YPEL3 alter the sensory circuit function in
RT Drosophila.";
RL Dis. Model. Mech. 13:0-0(2020).
CC -!- FUNCTION: Involved in regulating synaptic transmission in presynaptic
CC neurons (PubMed:32461240). In class IV dendritic arborization neurons
CC (nociceptors), involved in regulating activation of their second-order
CC neurons (SONs) and maintaining synaptic contact between nociceptors and
CC their SONs (PubMed:32461240). {ECO:0000269|PubMed:32461240}.
CC -!- DEVELOPMENTAL STAGE: In larvae, predominantly expressed in subsets of
CC neurons, including a subset of sensory neurons comprising the class IV
CC dendritic arborization (da) neurons (nociceptors), class III da neurons
CC and chordotonal neurons (both mechanosensors).
CC {ECO:0000269|PubMed:32461240}.
CC -!- DISRUPTION PHENOTYPE: Larvae display reduced nociceptive rolling
CC behavior due to impaired activation of second-order neurons (SONs) in
CC the nociceptive pathway and reduced the synaptic contact between
CC nociceptors and their SONs. {ECO:0000269|PubMed:32461240}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46560.1; -; Genomic_DNA.
DR EMBL; AE014298; ABW09382.1; -; Genomic_DNA.
DR EMBL; AY060270; AAL25309.1; -; mRNA.
DR RefSeq; NP_001096936.1; NM_001103466.3.
DR RefSeq; NP_001259394.1; NM_001272465.1.
DR RefSeq; NP_001259395.1; NM_001272466.1.
DR RefSeq; NP_001259396.1; NM_001272467.1.
DR RefSeq; NP_572609.1; NM_132381.4.
DR AlphaFoldDB; Q9W2X7; -.
DR BioGRID; 58384; 4.
DR IntAct; Q9W2X7; 1.
DR STRING; 7227.FBpp0305119; -.
DR PaxDb; Q9W2X7; -.
DR DNASU; 31949; -.
DR EnsemblMetazoa; FBtr0071487; FBpp0071416; FBgn0030183.
DR EnsemblMetazoa; FBtr0112974; FBpp0111887; FBgn0030183.
DR EnsemblMetazoa; FBtr0332898; FBpp0305119; FBgn0030183.
DR EnsemblMetazoa; FBtr0332899; FBpp0305120; FBgn0030183.
DR EnsemblMetazoa; FBtr0332900; FBpp0305121; FBgn0030183.
DR GeneID; 31949; -.
DR KEGG; dme:Dmel_CG15309; -.
DR UCSC; CG15309-RA; d. melanogaster.
DR FlyBase; FBgn0030183; Ypel.
DR VEuPathDB; VectorBase:FBgn0030183; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000159010; -.
DR HOGENOM; CLU_043857_3_2_1; -.
DR InParanoid; Q9W2X7; -.
DR OMA; GQHGKAF; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; Q9W2X7; -.
DR SignaLink; Q9W2X7; -.
DR BioGRID-ORCS; 31949; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG15309; fly.
DR GenomeRNAi; 31949; -.
DR PRO; PR:Q9W2X7; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030183; Expressed in second segment of antenna (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9W2X7; baseline and differential.
DR Genevisible; Q9W2X7; DM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050807; P:regulation of synapse organization; IMP:FlyBase.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..114
FT /note="Protein yippee-like"
FT /id="PRO_0000212401"
FT DOMAIN 14..111
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 21
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ SEQUENCE 114 AA; 12923 MW; D4F650313385C06D CRC64;
MVKTFQAYLP STNRTYSCVH CRAHLASHDE LISKSFQGSQ GPAYLFNSVV NVACGQTEER
VLLTGLHAVA DIYCECCKTP LGWKYEHAYE SSQKYKEGKF IIELAHMIKE NGWD
