YPL2_CAEEL
ID YPL2_CAEEL Reviewed; 161 AA.
AC O44440; Q86S45;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein yippee-like B0546.4;
GN ORFNames=B0546.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O44440-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O44440-2; Sequence=VSP_015666;
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; FO080229; CCD62189.1; -; Genomic_DNA.
DR EMBL; FO080229; CCD62190.1; -; Genomic_DNA.
DR PIR; T32587; T32587.
DR RefSeq; NP_500335.1; NM_067934.3. [O44440-1]
DR RefSeq; NP_872097.1; NM_182297.3.
DR AlphaFoldDB; O44440; -.
DR STRING; 6239.B0546.4a; -.
DR EPD; O44440; -.
DR PaxDb; O44440; -.
DR EnsemblMetazoa; B0546.4a.1; B0546.4a.1; WBGene00015251. [O44440-1]
DR GeneID; 177105; -.
DR KEGG; cel:CELE_B0546.4; -.
DR UCSC; B0546.4b; c. elegans. [O44440-1]
DR CTD; 177105; -.
DR WormBase; B0546.4a; CE16795; WBGene00015251; -. [O44440-1]
DR WormBase; B0546.4b; CE33354; WBGene00015251; -. [O44440-2]
DR eggNOG; KOG3399; Eukaryota.
DR HOGENOM; CLU_043857_1_1_1; -.
DR InParanoid; O44440; -.
DR OMA; RAWNITH; -.
DR OrthoDB; 1431042at2759; -.
DR PhylomeDB; O44440; -.
DR PRO; PR:O44440; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00015251; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; O44440; baseline and differential.
DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..161
FT /note="Protein yippee-like B0546.4"
FT /id="PRO_0000212400"
FT DOMAIN 14..111
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT REGION 117..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 21
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT VAR_SEQ 123..161
FT /note="QEAPPAPNLEMSRYPLEAEKKSRPQYRTVSVSSSSSAEC -> FVLVFQKKI
FT DFV (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015666"
SQ SEQUENCE 161 AA; 17914 MW; F097245F09E4F804 CRC64;
MGRQFAGICG ARGSLYGCVV CNTYLTCSKE LTSKAFTGST GPATLFKRAW NVVYGRCEHR
KMTTGWHTVR DVFCVTCNQK LGWMYEMAVS ESQTYKETQV IIENANFEKI AGAIKDPLGE
DRQEAPPAPN LEMSRYPLEA EKKSRPQYRT VSVSSSSSAE C
