YPP1_SCHPO
ID YPP1_SCHPO Reviewed; 862 AA.
AC O94441;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Putative cargo-transport protein ypp1;
GN Name=ypp1; ORFNames=SPAC637.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-633 AND SER-637, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in endocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Note=Found at the cell tip and the barrier septum.
CC -!- SIMILARITY: Belongs to the YPP1 family. {ECO:0000305}.
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DR EMBL; CU329670; CAA22583.1; -; Genomic_DNA.
DR PIR; T38996; T38996.
DR RefSeq; NP_594622.1; NM_001020050.2.
DR AlphaFoldDB; O94441; -.
DR SMR; O94441; -.
DR BioGRID; 279649; 22.
DR STRING; 4896.SPAC637.04.1; -.
DR iPTMnet; O94441; -.
DR MaxQB; O94441; -.
DR PaxDb; O94441; -.
DR PRIDE; O94441; -.
DR EnsemblFungi; SPAC637.04.1; SPAC637.04.1:pep; SPAC637.04.
DR GeneID; 2543221; -.
DR KEGG; spo:SPAC637.04; -.
DR PomBase; SPAC637.04; ypp1.
DR VEuPathDB; FungiDB:SPAC637.04; -.
DR eggNOG; KOG4162; Eukaryota.
DR HOGENOM; CLU_003276_1_0_1; -.
DR InParanoid; O94441; -.
DR OMA; CNGDWQA; -.
DR PhylomeDB; O94441; -.
DR PRO; PR:O94441; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0006897; P:endocytosis; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..862
FT /note="Putative cargo-transport protein ypp1"
FT /id="PRO_0000363379"
FT REPEAT 342..377
FT /note="TPR 1"
FT REPEAT 460..493
FT /note="TPR 2"
FT REPEAT 494..527
FT /note="TPR 3"
FT REPEAT 665..698
FT /note="TPR 4"
FT REPEAT 705..738
FT /note="TPR 5"
FT REPEAT 740..772
FT /note="TPR 6"
FT REPEAT 814..847
FT /note="TPR 7"
FT MOD_RES 632
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 633
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 637
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 862 AA; 98307 MW; EC51223B41ED23B6 CRC64;
MFSAKAKTYE LKLEQTRCNG DWQAIPEVAR KLHKHNSSKS FVCELAKIEA SLKSALTAEL
KNIANVLEPK LIDNQYSLIP ALPSARTDPL LSQLNSLNIQ NATEDEKLQE TSIRLLLYIV
QRKFPEAVDL DWSPQGIPWT ETSTGICILQ ATVLSSLAQY AQANDEVAYQ YVRSAIGLIQ
NANIGKKPLP ELTRWCDLAY SLYAQMSVSA CSSQLERANI LTTCLSYFTE HKSVNLLYKL
VTSRQAIKYL EHILRTNTNG SKIFTKSPVK NLYLNWPQLV LDYGSLLCNF TSFPKAGDQN
MFAVEFIELA TSIWINTEKS YDITVSLIRM LYQLTGKCFQ AQQIFRSLVF FLRHIEEFEE
ASEAFEIYKF LCVKSHERLA RKNSDVAGSF SDIKPVFVDE PKSIIEVCSV MMTVYAQYLR
NLKKVSEILD YITKIASDYD LLKRDDIAPL IYHTEGVAYS FMYYQANNPS LRERYHQKSV
QSYQKCLEKQ PTNTNALFHL AMQYSERRAI TDAMQIVRRL LEVNPKYSIV SWHLLVLCVS
CSEQYAAGIK LIDSVFETWG INHVNEDGTI EISLTNLTFN DRCALVDLLI TKLALFEAEK
GVEATLDIQD EIFTLFASIF DLNEYRISKE GSSDELSTLL ERSTIQSIKS SKKISKDVEN
EKGSILGFSR KSSLKRSTVL SKKSHSSYKE NFQLRRGKTV SYLNQKLWLT AASLFLKSGN
DDQARSALLE AKKIDHECAW VYYLNGLSLL QQGKEVEGYE QLDVAHYLDP EDPLISTALA
KCLLQGGYGP MHSRRNRADA ILSSCTLQYG WDLPEAWYYT AEIFRQLGDL KQAAFSYDYC
IQLADTNPVR RWSNLQPRFM NV
