ID   YPP1_YEAS7              Reviewed;         817 AA.
AC   A6ZUK8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Cargo-transport protein YPP1;
DE   AltName: Full=Alpha-synuclein protective protein 1;
GN   Name=YPP1; ORFNames=SCY_2091;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Involved in endocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STT4 and ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YPP1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000100; EDN61785.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZUK8; -.
DR   SMR; A6ZUK8; -.
DR   PRIDE; A6ZUK8; -.
DR   EnsemblFungi; EDN61785; EDN61785; SCY_2091.
DR   HOGENOM; CLU_019616_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endocytosis; Membrane.
FT   CHAIN           1..817
FT                   /note="Cargo-transport protein YPP1"
FT                   /id="PRO_0000308809"
SQ   SEQUENCE   817 AA;  95342 MW;  0A82CB0A42182E0D CRC64;
     MPNSNVRIPP TVPSKIIDVV DQALRARLLG GSTFNSGFDS LDSVLNLQFR LHYHVIGSNG
     PAKPVCDVLL KESQNLEKNM SMMEELNDYP EITKLVEKIL FNCLAILFFH RGQFQESQRC
     LLHSLKIHNN TASQRTALME QYDRYLIVEN LYYRGLVSQD INIMQNVFYK ELLAHVDTVP
     PESNGLLFEY ISLIVAKLRF NQIQDLAENF KTTVENPFIL FLYMIKKFQS PLKKHIDNDD
     LYLKFGQNVL LKVKFPTASE TNDEALEHFN VFLQYYFKFT HIKKIKVNPS WYNFIISSME
     KTFQSIEVSK TAMFLFQNLS DNSNDEIKKK TFKRESILNF VNFVKYNDKY YQLHDNSHHD
     IISFIDAYSF ILQNSSKTDS IENVFDYDNT VSTFATSLNS FYKEYNLPLM SQSESLDWLE
     NSTRCVYPGN ISKVLTNAWS TLYEIRKCQL DFLVSNNLTS YLCNAMMLST KEKDNADVEE
     QEEGEEEKAL RELQFKYSYT LAQQRHIETA IKTLESLILS KNPNYYKAWH LLALCRSVQE
     DKEMSYKIVC SVLEAMNESL QNNTLLLNDR WQFIHLKLTQ LALIEEIFGT LEALETLPEV
     FELYATLFPD SQPKLNSMGP KYSQTKEYLL QMVWIFAANM YMRTKDNDED AKAAIKEASN
     VESKFKNLNC NIANGYLSII KDEPGVALKE FETVLYYDEN NLDALVGFAE LIFPEELGVE
     ETNLERYYTL SLDKKPGKRA KLTFVNDTDR SAAYARLKFL LECAILESIE AYYSPEVWWY
     LSLIYEKYQD DEYKNSLLKC IKYQELNPIR SLRYCNY