YPP4_CAEEL
ID YPP4_CAEEL Reviewed; 243 AA.
AC Q19948; Q8IG24;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Uncharacterized protein F32A5.4;
DE Flags: Precursor;
GN ORFNames=F32A5.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-55, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-55, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q19948-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q19948-2; Sequence=VSP_007539;
CC -!- SIMILARITY: Belongs to the protease inhibitor I33 family.
CC {ECO:0000305}.
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DR EMBL; FO080735; CCD66274.1; -; Genomic_DNA.
DR EMBL; FO080735; CCD66275.1; -; Genomic_DNA.
DR PIR; T16229; T16229.
DR RefSeq; NP_495508.1; NM_063107.3. [Q19948-1]
DR RefSeq; NP_871977.1; NM_182177.3. [Q19948-2]
DR AlphaFoldDB; Q19948; -.
DR BioGRID; 39524; 8.
DR STRING; 6239.F32A5.4a.2; -.
DR MEROPS; I33.002; -.
DR iPTMnet; Q19948; -.
DR EPD; Q19948; -.
DR PaxDb; Q19948; -.
DR PeptideAtlas; Q19948; -.
DR EnsemblMetazoa; F32A5.4a.1; F32A5.4a.1; WBGene00017970. [Q19948-1]
DR EnsemblMetazoa; F32A5.4b.1; F32A5.4b.1; WBGene00017970. [Q19948-2]
DR GeneID; 174188; -.
DR KEGG; cel:CELE_F32A5.4; -.
DR UCSC; F32A5.4a.1; c. elegans. [Q19948-1]
DR CTD; 174188; -.
DR WormBase; F32A5.4a; CE01274; WBGene00017970; -. [Q19948-1]
DR WormBase; F32A5.4b; CE32640; WBGene00017970; -. [Q19948-2]
DR eggNOG; ENOG502S3IQ; Eukaryota.
DR GeneTree; ENSGT00970000196274; -.
DR HOGENOM; CLU_099985_0_0_1; -.
DR InParanoid; Q19948; -.
DR OMA; YFDGCMV; -.
DR OrthoDB; 1378670at2759; -.
DR PRO; PR:Q19948; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00017970; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.1120.50; -; 2.
DR InterPro; IPR010480; Pepsin-I3.
DR InterPro; IPR038412; Pepsin-I3_sf.
DR Pfam; PF06394; Pepsin-I3; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..243
FT /note="Uncharacterized protein F32A5.4"
FT /id="PRO_0000002401"
FT REGION 95..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT DISULFID 141..239
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..76
FT /note="MKLLALVALCAVGVASHRDKRQLSIGTISVSGAGGSTGCVVTGNVLYANGIR
FT LRNLTSSEQSELATYQTEVEQYKT -> MTWHFFQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_007539"
SQ SEQUENCE 243 AA; 26463 MW; F8549B0E253D2F44 CRC64;
MKLLALVALC AVGVASHRDK RQLSIGTISV SGAGGSTGCV VTGNVLYANG IRLRNLTSSE
QSELATYQTE VEQYKTQLRN ILSQRRENLR NRLMSQGRNQ QQQSNDVSSQ GGNDDGSIPK
APEKPSFCTA EDTTQYYFDG CMVQGNKVYV GGQYARDLSS DEISELQTFD TQQTAYQNAV
QSQMQSQVQG LFGGSDFLSA LFGGDRFNQQ QQRQQPSSTT PASTSSTTLP PKPTVPQFCT
AIF
