YPRA_BACSU
ID YPRA_BACSU Reviewed; 749 AA.
AC P50830;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized ATP-dependent helicase YprA;
DE EC=3.6.4.-;
GN Name=yprA; OrderedLocusNames=BSU22220;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA Serror P.;
RT "Sequence analysis of the Bacillus subtilis chromosome region between the
RT serA and kdg loci cloned in a yeast artificial chromosome.";
RL Microbiology 142:2005-2016(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR EMBL; L47838; AAB38468.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14139.1; -; Genomic_DNA.
DR PIR; B69941; B69941.
DR RefSeq; NP_390104.1; NC_000964.3.
DR RefSeq; WP_003246149.1; NZ_JNCM01000036.1.
DR PDB; 6ZNP; X-ray; 3.16 A; A/B=1-749.
DR PDB; 6ZNQ; X-ray; 3.34 A; A/B=1-749.
DR PDB; 6ZNS; X-ray; 3.32 A; A=1-749.
DR PDBsum; 6ZNP; -.
DR PDBsum; 6ZNQ; -.
DR PDBsum; 6ZNS; -.
DR AlphaFoldDB; P50830; -.
DR SMR; P50830; -.
DR STRING; 224308.BSU22220; -.
DR PaxDb; P50830; -.
DR PRIDE; P50830; -.
DR EnsemblBacteria; CAB14139; CAB14139; BSU_22220.
DR GeneID; 939052; -.
DR KEGG; bsu:BSU22220; -.
DR PATRIC; fig|224308.179.peg.2426; -.
DR eggNOG; COG1111; Bacteria.
DR eggNOG; COG1205; Bacteria.
DR InParanoid; P50830; -.
DR OMA; CIQSPKC; -.
DR PhylomeDB; P50830; -.
DR BioCyc; BSUB:BSU22220-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR018973; MZB.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF09369; DUF1998; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Helicase; Hydrolase; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..749
FT /note="Uncharacterized ATP-dependent helicase YprA"
FT /id="PRO_0000102195"
FT DOMAIN 63..243
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 276..430
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 185..188
FT /note="DEVH box"
FT BINDING 76..83
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT HELIX 6..14
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 15..17
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 19..25
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 32..34
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 41..48
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 57..68
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 78..80
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 82..96
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 101..105
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 109..125
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 132..134
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 136..139
FT /evidence="ECO:0007829|PDB:6ZNS"
FT HELIX 141..150
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 152..156
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 158..163
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 166..171
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 173..176
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 179..185
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 192..211
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 217..221
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 228..236
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 253..258
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 262..264
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 265..268
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 273..286
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 291..294
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 298..312
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 313..315
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 321..324
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 330..342
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 347..350
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 352..355
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 363..370
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 375..382
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 388..390
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 392..397
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 402..409
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 411..416
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 429..442
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 445..449
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 451..454
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 457..465
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 468..472
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 475..478
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 479..481
FT /evidence="ECO:0007829|PDB:6ZNS"
FT HELIX 485..487
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 490..493
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 494..496
FT /evidence="ECO:0007829|PDB:6ZNS"
FT STRAND 497..502
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 506..508
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 510..516
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 517..523
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 529..532
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 535..543
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 544..547
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 548..553
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 557..562
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 565..579
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 582..594
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 597..602
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 603..605
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 608..613
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 619..630
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 639..660
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 665..667
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 668..675
FT /evidence="ECO:0007829|PDB:6ZNP"
FT TURN 677..679
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 683..688
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 690..692
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 696..702
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 704..717
FT /evidence="ECO:0007829|PDB:6ZNP"
FT STRAND 719..722
FT /evidence="ECO:0007829|PDB:6ZNS"
FT TURN 725..728
FT /evidence="ECO:0007829|PDB:6ZNP"
FT HELIX 737..747
FT /evidence="ECO:0007829|PDB:6ZNP"
SQ SEQUENCE 749 AA; 84590 MW; 3F653EFA8EC3A7EE CRC64;
MKKKSLTELI SDLKGNENVV NWHEIEPREA KTRPMPESID ERIKAALSKR GIDELYTHQY
SAFQYVQKGE SIVTVTPTAS GKTLCYNLPV LQSIAQDETN RALYLFPTKA LAQDQKSELN
EIIDEMGIDI KSFTYDGDTS PAIRQKVRKA GHIVITNPDM LHSAILPHHT KWVSLFENLK
YIVIDELHTY RGVFGSHVAN VIRRLKRICR FYGSDPVFIC TSATIANPKE LGEQLTGKPM
RLVDDNGAPS GRKHFVFYNP PIVNKPLNIR RSATAEVNEL AKEFLKNKVQ TIVFARSRVR
VEIILSHIQE LVKKEIGTKS IRGYRGGYLP KERREIERGL REGDILGVVS TNALELGVDI
GQLQVCVMTG YPGSVASAWQ QAGRAGRRHG ESLIIMVANS TPIDQYIVRH PEYFFNRSPE
SARINPENLI ILVDHLKCAA YELPFRADEE FGAMEVSDIL EYLQEEAVLH RNGERYHWAS
ESFPASNISL RSASQENVVI VDQSDIANVR IIGEMDRFSA MTLLHDEAIY LHEGVQYQVE
KLDWDHKKAY VRKVDVEYYT DANLAVQLKV LEIDKTKEKS RTSLHYGDVT VNALPTIFKK
IKMTTFENIG SGPIHLPEEE LHTSAAWLEI KTADEDIGEK TLEQLLLGIS NVLQHIVPVY
IMCDRNDVHV VSQIKAAHTG LPTIFLYDHY PGGIGLAEEV FKRFSDINEA AKQLITHCPC
HDGCPSCIGT EIEGIKAKER ILQLLDQMS
