YPS5_YEAST
ID YPS5_YEAST Reviewed; 165 AA.
AC P53057; D6VV75;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Yapsin-5;
DE AltName: Full=Aspartic proteinase-like protein YPS5;
DE Flags: Precursor;
GN Name=YPS5; OrderedLocusNames=YGL259W; ORFNames=NRA165;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972578;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1555::aid-yea43>3.0.co;2-q;
RA Coissac E., Maillier E., Robineau S., Netter P.;
RT "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome
RT VII of Saccharomyces cerevisiae.";
RL Yeast 12:1555-1562(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP GENE NAME.
RX PubMed=10191273; DOI=10.1042/bj3390407;
RA Olsen V., Cawley N.X., Brandt J., Egel-Mitani M., Loh Y.P.;
RT "Identification and characterization of Saccharomyces cerevisiae yapsin 3,
RT a new member of the yapsin family of aspartic proteases encoded by the YPS3
RT gene.";
RL Biochem. J. 339:407-411(1999).
CC -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. Contains only the N-ter
CC part of the functional aspartic proteinases. {ECO:0000305}.
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DR EMBL; X94357; CAA64128.1; -; Genomic_DNA.
DR EMBL; Z72781; CAA96979.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07859.1; -; Genomic_DNA.
DR PIR; S61602; S61602.
DR RefSeq; NP_011255.1; NM_001181125.1.
DR AlphaFoldDB; P53057; -.
DR BioGRID; 33019; 40.
DR DIP; DIP-4875N; -.
DR IntAct; P53057; 1.
DR MINT; P53057; -.
DR STRING; 4932.YGL259W; -.
DR MEROPS; A01.A62; -.
DR PaxDb; P53057; -.
DR EnsemblFungi; YGL259W_mRNA; YGL259W; YGL259W.
DR GeneID; 852632; -.
DR KEGG; sce:YGL259W; -.
DR SGD; S000003228; YPS5.
DR VEuPathDB; FungiDB:YGL259W; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_146433_0_0_1; -.
DR BioCyc; YEAST:G3O-30727-MON; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53057; protein.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; ISS:SGD.
DR Gene3D; 2.40.70.10; -; 1.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; SSF50630; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 5: Uncertain;
KW Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..165
FT /note="Yapsin-5"
FT /id="PRO_0000014320"
FT DOMAIN 67..165
FT /note="Peptidase A1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 165 AA; 17953 MW; 0B6445C18BE45EB3 CRC64;
MQLFSILSLL SSLMCSLTVL GSSASSYVKF PVQKFADIIN IGTQDVSTVF KRNEVLNTTV
INGIGVYVVK MEIGTPPQTV YLQLDTGSSD MIVNNADIAY CKSMSDGSDY ASTDNYELTA
TFTGPRSTTT SPELITLSAL IGVNSMQETH LLLRITRLSS MTYTY
