ID   YPSC_BACSU              Reviewed;         385 AA.
AC   P50840;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative RNA methyltransferase YpsC;
DE            EC=2.1.1.-;
GN   Name=ypsC; OrderedLocusNames=BSU22170;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA   Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA   Serror P.;
RT   "Sequence analysis of the Bacillus subtilis chromosome region between the
RT   serA and kdg loci cloned in a yeast artificial chromosome.";
RL   Microbiology 142:2005-2016(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124.
RX   PubMed=2423526; DOI=10.1016/s0021-9258(19)57486-5;
RA   Reich C., Gardiner K.J., Olsen G.J., Pace B., Marsh T.L., Pace N.R.;
RT   "The RNA component of the Bacillus subtilis RNase P. Sequence, activity,
RT   and partial secondary structure.";
RL   J. Biol. Chem. 261:7888-7893(1986).
RN   [4]
RP   SUBUNIT.
RC   STRAIN=168;
RX   PubMed=21710567; DOI=10.1002/pmic.201000790;
RA   Delumeau O., Lecointe F., Muntel J., Guillot A., Guedon E., Monnet V.,
RA   Hecker M., Becher D., Polard P., Noirot P.;
RT   "The dynamic protein partnership of RNA polymerase in Bacillus subtilis.";
RL   Proteomics 11:2992-3001(2011).
CC   -!- SUBUNIT: Interacts with the RNA polymerase core.
CC       {ECO:0000269|PubMed:21710567}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=M13175; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L47838; AAB38473.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14134.1; -; Genomic_DNA.
DR   EMBL; M13175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; F69941; F69941.
DR   RefSeq; NP_390099.1; NC_000964.3.
DR   RefSeq; WP_009967571.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P50840; -.
DR   SMR; P50840; -.
DR   STRING; 224308.BSU22170; -.
DR   PaxDb; P50840; -.
DR   PRIDE; P50840; -.
DR   EnsemblBacteria; CAB14134; CAB14134; BSU_22170.
DR   GeneID; 939057; -.
DR   KEGG; bsu:BSU22170; -.
DR   PATRIC; fig|224308.179.peg.2421; -.
DR   eggNOG; COG0116; Bacteria.
DR   InParanoid; P50840; -.
DR   OMA; GFMYKAN; -.
DR   PhylomeDB; P50840; -.
DR   BioCyc; BSUB:BSU22170-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008990; F:rRNA (guanine-N2-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0070043; F:rRNA (guanine-N7-)-methyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RNA_methylase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51165; THUMP; 1.
DR   PROSITE; PS01261; UPF0020; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..385
FT                   /note="Putative RNA methyltransferase YpsC"
FT                   /id="PRO_0000036182"
FT   DOMAIN          44..156
FT                   /note="THUMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00529"
SQ   SEQUENCE   385 AA;  43507 MW;  587792F17E82B3B6 CRC64;
     MKKYTLIATA PMGIEAVVAK EVRDLGYECK VDNGKVIFEG DALAICRANL WLRTADRIKV
     QVASFKAKTF DELFEKTKAI NWRSFIPENG KFPVIGKSVK STLASVPDCQ RIVKKAIVEK
     LKLQSGKAND WIEETGAEYK VEISLLKDQA LITLDSSGTG LHKRGYRVDQ GGAPIKETLA
     AALVQLTNWT PDRPFVDPFC GSGTIAIEAA LIGQNIAPGF NRDFVSEDWE WIGKDLWNKA
     RLEVEEKANY DQPLTIFASD IDHRMVQIAK ENAEEAGLGD LIQFKQMQVK DFTTNLEFGV
     IVGNPPYGER LGEKKAVEQM YKEMGQAFEP LDTWSVYMLT SNENFEEAYG RKATKKRKLF
     NGFIKTDYYQ YWSKVRPQRK KTENA