ID   YPT35_ASHGO             Reviewed;         171 AA.
AC   Q75CM7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE   AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN   Name=YPT35; OrderedLocusNames=ACL108C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 24; 27; 55-57; 66-67; 71 AND
RP   73.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC       vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC       (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51120.2; -; Genomic_DNA.
DR   RefSeq; NP_983296.2; NM_208649.2.
DR   AlphaFoldDB; Q75CM7; -.
DR   SMR; Q75CM7; -.
DR   STRING; 33169.AAS51120; -.
DR   EnsemblFungi; AAS51120; AAS51120; AGOS_ACL108C.
DR   GeneID; 4619416; -.
DR   KEGG; ago:AGOS_ACL108C; -.
DR   eggNOG; ENOG502S40T; Eukaryota.
DR   HOGENOM; CLU_1475537_0_0_1; -.
DR   InParanoid; Q75CM7; -.
DR   OMA; FAVWKIT; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR   GO; GO:0036010; P:protein localization to endosome; IEA:EnsemblFungi.
DR   GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR   CDD; cd07280; PX_YPT35; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR037917; Ypt35_PX.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..171
FT                   /note="Endosomal/vacuolar adapter protein YPT35"
FT                   /id="PRO_0000333491"
FT   DOMAIN          1..164
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ   SEQUENCE   171 AA;  19131 MW;  206CF2E1918970DE CRC64;
     MPHIQFLPPE PVVLVSRVAD DPDPAGPGLH VAKVAVGDCT IVDARTPCAP LQGRFAVWTV
     ALQLHSPDTP RSLTLRKRYS DFVRFRERLL LCLPPPLRRA VPPLPPPVPW YDAWRYSDVN
     LDRAWLAARR AGLERFLQQV LLNRALVAAA PVVVRGFLEP PAAHRWVPVR A