ID   YPT35_CANGA             Reviewed;         173 AA.
AC   Q6FR40;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE   AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN   Name=YPT35; OrderedLocusNames=CAGL0I01144g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC       vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC       (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
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DR   EMBL; CR380955; CAG60241.1; -; Genomic_DNA.
DR   RefSeq; XP_447304.1; XM_447304.1.
DR   AlphaFoldDB; Q6FR40; -.
DR   SMR; Q6FR40; -.
DR   STRING; 5478.XP_447304.1; -.
DR   EnsemblFungi; CAG60241; CAG60241; CAGL0I01144g.
DR   GeneID; 2889335; -.
DR   KEGG; cgr:CAGL0I01144g; -.
DR   CGD; CAL0132214; CAGL0I01144g.
DR   VEuPathDB; FungiDB:CAGL0I01144g; -.
DR   eggNOG; ENOG502S40T; Eukaryota.
DR   HOGENOM; CLU_1475537_0_0_1; -.
DR   InParanoid; Q6FR40; -.
DR   OMA; FAVWKIT; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR   GO; GO:0036010; P:protein localization to endosome; IEA:EnsemblFungi.
DR   GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR   CDD; cd07280; PX_YPT35; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR037917; Ypt35_PX.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..173
FT                   /note="Endosomal/vacuolar adapter protein YPT35"
FT                   /id="PRO_0000333493"
FT   DOMAIN          40..173
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ   SEQUENCE   173 AA;  20009 MW;  9F44137EF712EDEF CRC64;
     MADKVAVLDP EPITLLDTED EPGISQSRRS SIANSNFYIE RAFVTNCTII SGERSTPKFA
     VWKVTAVLHP LNPNSSGSYR IHTYKRYSDF VEFRNALLDR VRTKRPASVS EIPELPPPVK
     WYYSWKYNEI NLNKEWLANR RKGLELFINQ VLLNGNIVDI AKDLVIQFLR PRK