ID   YPT35_DEBHA             Reviewed;         157 AA.
AC   Q6BIS2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE   AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN   Name=YPT35; OrderedLocusNames=DEHA2G08074g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC       vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC       (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90362.2; -; Genomic_DNA.
DR   RefSeq; XP_461899.2; XM_461899.1.
DR   AlphaFoldDB; Q6BIS2; -.
DR   SMR; Q6BIS2; -.
DR   EnsemblFungi; CAG90362; CAG90362; DEHA2G08074g.
DR   GeneID; 2904780; -.
DR   KEGG; dha:DEHA2G08074g; -.
DR   VEuPathDB; FungiDB:DEHA2G08074g; -.
DR   eggNOG; ENOG502S8A5; Eukaryota.
DR   HOGENOM; CLU_070610_2_0_1; -.
DR   InParanoid; Q6BIS2; -.
DR   OMA; QWFMTNV; -.
DR   OrthoDB; 1517214at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR   GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR   CDD; cd07280; PX_YPT35; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR037917; Ypt35_PX.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..157
FT                   /note="Endosomal/vacuolar adapter protein YPT35"
FT                   /id="PRO_0000333494"
FT   DOMAIN          43..157
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ   SEQUENCE   157 AA;  18205 MW;  4F1E60FD46377244 CRC64;
     MTASNRRGST HRNSVTQLNK VLPVPIQLED ETSSGHFNST SHITDVLVGD YHVIQGEGGS
     SYVVWSIRII VDDSVYSSMV IYKRYSDIQR FREALLEHYP NTEIPPLPPK DNFSFQRLSM
     SDYWLENRRK GLQWFMTNVM LNPKHQHSPV ITHFILN