YPT35_PICGU
ID YPT35_PICGU Reviewed; 145 AA.
AC A5DHC9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN Name=YPT35; ORFNames=PGUG_02680;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P38815}.
CC -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC {ECO:0000250|UniProtKB:P38815}.
CC -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408157; EDK38582.2; -; Genomic_DNA.
DR RefSeq; XP_001484951.1; XM_001484901.1.
DR AlphaFoldDB; A5DHC9; -.
DR SMR; A5DHC9; -.
DR EnsemblFungi; EDK38582; EDK38582; PGUG_02680.
DR GeneID; 5126653; -.
DR KEGG; pgu:PGUG_02680; -.
DR eggNOG; ENOG502S8A5; Eukaryota.
DR HOGENOM; CLU_070610_2_0_1; -.
DR InParanoid; A5DHC9; -.
DR OMA; QWFMTNV; -.
DR OrthoDB; 1517214at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR CDD; cd07280; PX_YPT35; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037917; Ypt35_PX.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Reference proteome; Vacuole.
FT CHAIN 1..145
FT /note="Endosomal/vacuolar adapter protein YPT35"
FT /id="PRO_0000333495"
FT DOMAIN 32..145
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ SEQUENCE 145 AA; 16807 MW; F5CDA4FB32B80EA2 CRC64;
MVANTSMRLN QVAPVPIQLE DHGPNQLEPT HISDVLVGEH HTIKGENGQS YVVWAIRIIV
NDSIYSSIVL YKRYREMEAF RNKLLDEFGN EIPPLPPKDS MSLQKLTNPL AWLEERRKGL
QWFMTNVLLN PRWQRSTVVR EFVLG
