ID   YPT35_VANPO             Reviewed;         174 AA.
AC   A7TKX9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE   AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN   Name=YPT35; ORFNames=Kpol_530p4;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC       vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC       (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC       {ECO:0000250|UniProtKB:P38815}.
CC   -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
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DR   EMBL; DS480411; EDO17035.1; -; Genomic_DNA.
DR   RefSeq; XP_001644893.1; XM_001644843.1.
DR   AlphaFoldDB; A7TKX9; -.
DR   SMR; A7TKX9; -.
DR   STRING; 436907.A7TKX9; -.
DR   EnsemblFungi; EDO17035; EDO17035; Kpol_530p4.
DR   GeneID; 5545225; -.
DR   KEGG; vpo:Kpol_530p4; -.
DR   eggNOG; ENOG502S40T; Eukaryota.
DR   HOGENOM; CLU_1475537_0_0_1; -.
DR   InParanoid; A7TKX9; -.
DR   OMA; FAVWKIT; -.
DR   OrthoDB; 1517214at2759; -.
DR   PhylomeDB; A7TKX9; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR   GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR   CDD; cd07280; PX_YPT35; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR037917; Ypt35_PX.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..174
FT                   /note="Endosomal/vacuolar adapter protein YPT35"
FT                   /id="PRO_0000333497"
FT   DOMAIN          34..168
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ   SEQUENCE   174 AA;  20267 MW;  17A8FC84863ACB1F CRC64;
     MSTRKLNMLT PEPIHLLEEG GDNSEEFVVD EGCQVQRIYV GDGSITTSDE AKFTIWKVTT
     ELIVHKVEPV RVSIPLEIVS YRRYSEFDQL RAEIISKIGK NVQVPELPPK VYWYDYWRFS
     KINLNRHWLN KRRQGLDNFI NKIIKNKDIM ESCAKEVNEF LGVSSDVSTR TNSE