ID   YPUA_BACSU              Reviewed;         290 AA.
AC   P31847; P37951;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Uncharacterized protein YpuA;
DE   AltName: Full=ORFX19;
GN   Name=ypuA; OrderedLocusNames=BSU23370;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=7934829; DOI=10.1111/j.1365-2958.1993.tb02670.x;
RA   Sorokin A.V., Zumstein E., Azevedo V., Ehrlich S.D., Serror P.;
RT   "The organization of the Bacillus subtilis 168 chromosome region between
RT   the spoVA and serA genetic loci, based on sequence data.";
RL   Mol. Microbiol. 10:385-395(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-290.
RX   PubMed=1368705; DOI=10.1271/bbb1961.55.1615;
RA   Yamamoto J., Shimizu M., Yamane K.;
RT   "Molecular cloning and analysis of nucleotide sequence of the Bacillus
RT   subtilis lysA gene region using B. subtilis phage vectors and a multi-copy
RT   plasmid, pUB110.";
RL   Agric. Biol. Chem. 55:1615-1626(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-290.
RC   STRAIN=168 / JH642;
RX   PubMed=8022278; DOI=10.1111/j.1365-2958.1994.tb00384.x;
RA   Herrler M., Bang H., Marahiel M.A.;
RT   "Cloning and characterization of ppiB, a Bacillus subtilis gene which
RT   encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase.";
RL   Mol. Microbiol. 11:1073-1083(1994).
RN   [5]
RP   INDUCTION.
RC   STRAIN=168 / 1604;
RX   PubMed=17434969; DOI=10.1128/jb.00130-07;
RA   Jervis A.J., Thackray P.D., Houston C.W., Horsburgh M.J., Moir A.;
RT   "SigM-responsive genes of Bacillus subtilis and their promoters.";
RL   J. Bacteriol. 189:4534-4538(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=22882210; DOI=10.1111/j.1365-2958.2012.08205.x;
RA   Yepes A., Schneider J., Mielich B., Koch G., Garcia-Betancur J.C.,
RA   Ramamurthi K.S., Vlamakis H., Lopez D.;
RT   "The biofilm formation defect of a Bacillus subtilis flotillin-defective
RT   mutant involves the protease FtsH.";
RL   Mol. Microbiol. 86:457-471(2012).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22882210}.
CC       Membrane raft {ECO:0000269|PubMed:22882210}. Note=Present in detergent-
CC       resistant membrane (DRM) fractions that may be equivalent to eukaryotic
CC       membrane rafts; these rafts include proteins involved in signaling,
CC       molecule trafficking and protein secretion.
CC       {ECO:0000269|PubMed:22882210}.
CC   -!- INDUCTION: Transcribed under partial control of SigM ECF sigma factor
CC       (PubMed:17434969). {ECO:0000269|PubMed:17434969}.
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DR   EMBL; L09228; AAA67474.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14269.1; -; Genomic_DNA.
DR   EMBL; D90189; BAA14212.1; -; Genomic_DNA.
DR   EMBL; X73898; CAA52102.1; -; Genomic_DNA.
DR   PIR; S45536; JU0473.
DR   RefSeq; NP_390218.1; NC_000964.3.
DR   RefSeq; WP_009967658.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P31847; -.
DR   SMR; P31847; -.
DR   STRING; 224308.BSU23370; -.
DR   jPOST; P31847; -.
DR   PaxDb; P31847; -.
DR   PRIDE; P31847; -.
DR   DNASU; 938939; -.
DR   EnsemblBacteria; CAB14269; CAB14269; BSU_23370.
DR   GeneID; 938939; -.
DR   KEGG; bsu:BSU23370; -.
DR   PATRIC; fig|224308.179.peg.2546; -.
DR   eggNOG; COG4086; Bacteria.
DR   OMA; EEHEYLG; -.
DR   PhylomeDB; P31847; -.
DR   BioCyc; BSUB:BSU23370-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009343; DUF1002.
DR   Pfam; PF06207; DUF1002; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..290
FT                   /note="Uncharacterized protein YpuA"
FT                   /id="PRO_0000049726"
SQ   SEQUENCE   290 AA;  31295 MW;  06F145CBB96DCDC3 CRC64;
     MKKIWIGMLA AAVLLLMVPK VSLADAAVGD VIVTLGADLS ESDKQKVLDE MNVPDNATTV
     TVTNKEEHEY LGKYISNAQI GSRAISSSSI TIAKKGSGLN VETHNISGIT DEMYLNALMT
     AGVKDAKVYV TAPFEVSGTA ALTGLIKAYE VSSDEAISED VKQVANQELV TTSELGDKIG
     NENAAALIAK IKEEFAKNGV PDNKADIEKQ VDDAASDLNV TLTDSQKNQL VSLFNKMKNA
     DIDWGQVSDQ LDKAKDKITK FIESDEGKNF IQKVIDFFVS IWNAIVSIFK